A case of drug-induced allergic hepatitis by herbal medicine.

靖紘, 溝口; 克仁郎, 吉安; ひろ子, 筒井; 慶治, 宮島; 吉秀, 阪上; 俊博, 東森; 守一, 関; 祐夫, 山本; 成司, 森沢

doi:10.2957/kanzo.26.376

Cited by 4 publications

(1 citation statement)

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“…Skin disorders such as exanthema, prutitus, and urticaria may be caused by allergic reactions to Kampo prescriptions. Although all medical herbs may potentially trigger allergic reactions, cinnamon bark, sesame oil, ginseng root, and Rehmannia root require particularly prudent prescription [26]. Cinnamon bark in JDI may cause rash.…”

Section: Discussionmentioning

confidence: 99%

Safety of jidabokuippo administration based on adverse event rate

Kitamura

Nakae

Irie

et al. 2022

Traditional & Kampo Medicine

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Aim The incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate. Methods Adverse events to JDI treatment were observed in 14 patients (adverse event group) while 1090 had none (non‐adverse event group). We compared age, sex, comorbidity, dose, dosing period, concomitant use of Kampo prescription, and concomitant use of analgesics between these two groups. Results The adverse event rate was 1.3%. The most common adverse event was diarrhea caused by rhubarb rhizome (0.6%). The adverse event rate of Glycyrrhiza‐induced pseudoaldosteronism was 0.3%. All symptoms improved on JDI withdrawal or taking JDI after meals. Median duration of JDI was significantly shorter in the adverse event group than in the non‐adverse event group (P = 0.0141). Conclusion The adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome and Glycyrrhiza root.

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Section: Discussionmentioning

confidence: 99%