“…In 1965, Lejeune et al 1965 suggested a tandem inverse duplication in these patients. Subsequently, a few cases have been published [Turleau et al, 1980; Pfeiffer and Loidl, 1982; Stoll et al, 1982; Pangalos et al, 1992b; Gutierrez‐Angulo et al, 1999; Barbi et al, 2000; Cortes‐Gutierrez et al, 2002; Wandall et al, 2002; Sheth et al, 2007; Egashira et al, 2008]. In this study, we report on a DS child with karyotype 46,XX,idic(21)(q22.3).…”