A Case of Disseminated<i>Mycobacterium avium</i>Infection in a Dog in Greece

Kontos, V.; Papadogiannakis, E.; Mantziaras, G.; Styliara, M.; Kanavaki, S.

doi:10.1155/2014/597847

Cited by 10 publications

(13 citation statements)

References 10 publications

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“…In most published canine case reports, the involved M. avium subspecies was not identified [67][68][69][70][71][72][73][74][75][76]. However, according to recent studies and unpublished data by authors, MAH appears to be the predominant pathogenic subspecies [77•, 78•, 79•, 80•].…”

Section: Mycobacterium Avium Complexmentioning

confidence: 99%

Mycobacterium avium: an Emerging Pathogen for Dog Breeds with Hereditary Immunodeficiencies

Ghielmetti

Giger

2020

Curr Clin Micro Rpt

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Purpose of Review Among the non-tuberculous mycobacteria (NTM), Mycobacterium avium complex (MAC) is the leading cause of pulmonary disease in humans. Innate and acquired immunodeficiencies have been associated with an increased host susceptibility to NTM infections. The underlying mechanisms predisposing humans and dogs to MAC infections are being elucidated. Recent Findings Although MAC infection is infrequently diagnosed in dogs, a strong breed predisposition particularly for Miniature Schnauzer and Basset Hound dogs is evident. A recessively inherited defect of the adaptor protein CARD9 has recently been documented to be responsible for the increased susceptibility to MAC in the Miniature Schnauzer breed. Summary Given the zoonotic potential of a MAC-infected dog particularly to immunocompromised human patients, diseased dogs pose a public health risk. While not a reportable disease, treatment of systemic mycobacteriosis is generally not effective and discouraged in dogs. The collaborative efforts by microbiologists, veterinary clinicians, dog breeders, primary care physicians, and infectious disease specialists applying the One Health approach are therefore crucial for the best management and prevention of MAC infection.

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Section: Mycobacterium Avium Complexmentioning

confidence: 99%

Mycobacterium avium: an Emerging Pathogen for Dog Breeds with Hereditary Immunodeficiencies

Ghielmetti

Giger

2020

Curr Clin Micro Rpt

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“…Mycobacterium avium-intracellulare complex (MAC) infections are becoming an increasing concern in veterinary medicine because they occur in a wide range of animals, including domestic animals ( 1 ), ruminant and non-ruminant wildlife ( 2 ), and companion animals ( 3 , 4 ). MAC includes two main species: M. avium and M. intracellulare ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…MAC infections are rare in dogs. Although only a small number of cases have been published, certain breeds, such as basset hounds and miniature schnauzers, seem to be at higher risk ( 3 , 4 , 6 , 7 ). MAC infections may cause granulomatous diseases, which range from localized granulomas to disseminated diseases.…”

Section: Introductionmentioning

confidence: 99%

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Isolation, Molecular Typing, and Antibiotic Susceptibility Testing of Mycobacterium avium Subspecies hominissuis From a Dog With Generalized Mycobacteriosis

Marianelli

Ape²,

Mori³

2020

Front. Vet. Sci.

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Mycobacterium avium-intracellulare complex infections are becoming an increasing concern in veterinary medicine because they affect livestock, wildlife, and companion animals. Here we describe the isolation, molecular typing, and antibiotic susceptibility testing of the causative agent of a rare case of generalized mycobacteriosis in a crossbred dog. Mycobacterial colonies were isolated from a popliteal lymph node aspirate sample and molecular typed by SNPs typing of the genes gyrB and rpsA , the 3′ region of the hsp65 gene and the internal transcribed spacer (ITS), and MIRU-VNTR analysis. Colonies were also tested in vitro against the macrolide clarithromycin and other drugs, using a resazurin microdilution assay, in order to provide the most appropriate treatment for the dog. Results from SNPs typing of gyrB and ITS, as well as from MIRU-VNTR analysis suggested the isolation of a single strain of M. avium subsp. hominissuis (Mah). On the other hand, SNP typing of rpsA revealed DNA polymorphisms that led colonies to cluster into two groups. The presence of two distinct strains of Mah has been assumed. All colonies, regardless of the nucleotide sequence of rpsA , were found to be sensitive to all of the drugs tested except for ethambutol. Although the therapy administered was adequate, the dog's overall clinical status worsened progressively and the animal died 8 months later. In conclusion, we report on the isolation of Mah from a dog with generalized mycobacteriosis.

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“…The MAC can cause infection in both humans and animals (7,12). In dogs, MAC infection has been recently described by PCR (5,13).…”

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confidence: 99%

Serological survey for antibodies against Mycobacterium avium complexin hunting dogs in East-Central Portugal

Coelho¹,

Matos²,

Figueira³

et al. 2016

Turk J Vet Anim Sci

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A Case of DisseminatedMycobacterium aviumInfection in a Dog in Greece

Cited by 10 publications

References 10 publications

Mycobacterium avium: an Emerging Pathogen for Dog Breeds with Hereditary Immunodeficiencies

Mycobacterium avium: an Emerging Pathogen for Dog Breeds with Hereditary Immunodeficiencies

Isolation, Molecular Typing, and Antibiotic Susceptibility Testing of Mycobacterium avium Subspecies hominissuis From a Dog With Generalized Mycobacteriosis

Serological survey for antibodies against Mycobacterium avium complexin hunting dogs in East-Central Portugal

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