“…Periodic breathing is well known [26,27], but in periodic breathing tidal volume and frequency alter together in an exaggeration of the normal tendency for larger breaths to be longer breaths. Neurological, cardiovascular or respiratory disease can disrupt ventilatory patterns, but both rhythm and volume tend to be affected [28,29]. Breathing that alternates between shorter, smaller breaths and longer, larger breaths can be explained by oscillations in chemical stimuli, although it usually requires low ventilatory frequencies and quite large chemical oscillations.…”