A case of dilated cardiomyopathy and severe mitral regurgitation treated using a combined percutaneous approach of MitraClip followed by CARILLON® mitral contour system

Abdelrahman, Nagwa; Chowdhury, Mohammed Andaleeb; Nooryani, Arif Al; Elabbassi, Wael

doi:10.1016/j.carrev.2016.07.001

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…Standalone surgical edge-to-edge leaflet repair has shown unsatisfactory long-term results (21). Both Carrilon (22) and Cardio-band (23) transcatheter annuloplasty devices been used to treat recurrent mitral regurgitation after Mitraclip (Abbott) procedures. Moreover, annuloplasty such as cerclage may provide a useful “landing zone” to implant transcatheter valves in native mitral valve disease.…”

Section: Discussionmentioning

confidence: 99%

Mitral Loop Cerclage Annuloplasty for Secondary Mitral Regurgitation

Park

Chon

Lederman

et al. 2017

JACC: Cardiovascular Interventions

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OBJECTIVES This is an early feasibility clinical test of mitral loop cerclage annuloplasty to treat secondary mitral valve regurgitation. BACKGROUND Secondary mitral regurgitation is characterized by cardiomyopathy, mitral annular enlargement, and leaflet traction contributing to malcoaptation. Transcatheter mitral loop cerclage applies circumferential compression to the mitral annulus by creating a loop through the coronary sinus across the interventricular septum, protecting entrapped coronary arteries from compression, and interactive annular reduction under echocardiographic guidance. This is the first human test of mitral loop annuloplasty. METHODS Five subjects with severe symptomatic secondary mitral regurgitation underwent mitral loop cerclage, with echocardiographic and computed tomography follow-up over 6 months. RESULTS Mitral loop cerclage was successful in 4 of 5 subjects and aborted in 1 of the 5 because of unsuitable septal coronary vein anatomy. Immediately and over 6 months, measures of both mitral valve regurgitation (effective orifice area and regurgitation fraction) and chamber dimensions (left atrial and left ventricular volumes) were reduced progressively and ejection fractions increased. Two with persistent and permanent atrial fibrillation spontaneously reverted to sinus rhythm during follow-up. One subject experienced a small myocardial infarction from an unrecognized small branch coronary occlusion. Another, experiencing cardiogenic shock at baseline, died of intractable heart failure after 6 weeks. CONCLUSIONS In this first human test, mitral loop cerclage annuloplasty was successful in 4 of 5 attempts, caused reverse remodeling (reduction in secondary mitral regurgitation and heart chamber volumes), and suggested electrical remodeling (reversion of atrial fibrillation). Further evaluation is warranted.

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Section: Discussionmentioning

confidence: 99%

Mitral Loop Cerclage Annuloplasty for Secondary Mitral Regurgitation

Park

Chon

Lederman

et al. 2017

JACC: Cardiovascular Interventions

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“…In this sense, there has been reported the first series of device combination therapy. Recently, experiences of direct and indirect TMVA after failure of PMVR with MitraClip ® have been published (64)(65)(66). MitraClip ® is currently the most widespread technique focus on MV leaflets, with contrasted effective results.…”

Section: Transcatheter Multimodal Approach For Mrmentioning

confidence: 99%

Percutaneous mitral repair: current and future devices

et al. 2020

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Mitral regurgitation (MR) is the second most common valvular heart disease and its prevalence is increasing with population ageing. In the recent years we have witnessed the development of several transcatheter devices to correct MR in patients at high-risk for surgery. The majority of evidence regarding safety and efficacy of this new therapy comes from MitraClip studies. However, new alternatives on the field of valve repair have emerged with promising results. The aim of this review is to portrait the landscape of transcatheter mitral repair alternatives, from currently used devices to those that will have a role in the near future.

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“…Different percutaneous techniques have been introduced to specifically target the MV annulus, including the CARILLON mitral contour system (Cardiac Dimensions Inc., Kirkland, WA, USA) and Cardioband (Valtech Cardio, Or Yehuda, Israel) devices for indirect and direct percutaneous MV annuloplasty, respectively. The feasibility of percutaneous annuloplasty after MitraClip implantation with either device has been recently reported [20,21]. …”

Section: Casementioning

confidence: 99%

Strategies and Outcomes of Repeat Mitral Valve Interventions after Failed MitraClip Therapy

Grasso

Buccheri²,

Capodanno³

et al. 2017

Cardiology

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Percutaneous mitral valve repair (PMVR) with the MitraClip system (Abbott Vascular, Santa Clara, CA, USA) is a valid therapeutic option for patients with severe mitral regurgitation (MR) deemed to be at high or prohibitive surgical risk. Despite the reassuring data on efficacy and long-term durability of the procedure, the proportion of patients with residual or relapsing severe MR after MitraClip therapy is not negligible. In light of the detrimental prognostic impact of severe MR, repeat interventions are increasingly performed in clinical practice using different techniques. In high-risk settings, percutaneous procedures have proven to be effective and safe at reducing MR. Building on this, we sought to summarize the current landscape and clinical experience of reinterventions after failed MitraClip therapy, so as to assist physicians facing the clinical hurdle of proper treatment management after failed PMVR.

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A case of dilated cardiomyopathy and severe mitral regurgitation treated using a combined percutaneous approach of MitraClip followed by CARILLON® mitral contour system

Cited by 12 publications

References 13 publications

Mitral Loop Cerclage Annuloplasty for Secondary Mitral Regurgitation

Mitral Loop Cerclage Annuloplasty for Secondary Mitral Regurgitation

Percutaneous mitral repair: current and future devices

Strategies and Outcomes of Repeat Mitral Valve Interventions after Failed MitraClip Therapy

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