A Case of Difficult Management of Fluid-electrolyte Imbalance in Choroid Plexus Papilloma

Saitô, Atsushi; Nishimura, Shinjitsu; Fujita, Tomoaki; Sasaki, Tatsuya; Nishijima, Michiharu

doi:10.2176/nmc.cr2012-0380

Cited by 2 publications

(2 citation statements)

References 10 publications

(21 reference statements)

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“…3,4,14,18,20,27,38,40,46,55,56,90,96,102,117,123,127 After surgical intervention (e.g., CPC or tumor removal), the rates of CSF production decreased, 4,20,35,46,51,90,96,117 and in some cases, there was no further need for a shunt. 27,51,56 In addition to CPP and CPH, overproduction of CSF contributing to hydrocephalus has also been implicated in idiopathic intracranial hypertension, 59 infectious hydrocephalus, 16 and intraventricular hemorrhage-associated hydrocephalus, 126 but secretion rates in the patients with these conditions have not been well documented.…”

Section: Hydrocephalus and Csf Productionmentioning

confidence: 99%

Cerebrospinal fluid hypersecretion in pediatric hydrocephalus

Karimy¹,

Durán²,

Hu³

et al. 2016

FOC

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Hydrocephalus, despite its heterogeneous causes, is ultimately a disease of disordered CSF homeostasis that results in pathological expansion of the cerebral ventricles. Our current understanding of the pathophysiology of hydrocephalus is inadequate but evolving. Over this past century, the majority of hydrocephalus cases has been explained by functional or anatomical obstructions to bulk CSF flow. More recently, hydrodynamic models of hydrocephalus have emphasized the role of abnormal intracranial pulsations in disease pathogenesis. Here, the authors review the molecular mechanisms of CSF secretion by the choroid plexus epithelium, the most efficient and actively secreting epithelium in the human body, and provide experimental and clinical evidence for the role of increased CSF production in hydrocephalus. Although the choroid plexus epithelium might have only an indirect influence on the pathogenesis of many types of pediatric hydrocephalus, the ability to modify CSF secretion with drugs newer than acetazolamide or furosemide would be an invaluable component of future therapies to alleviate permanent shunt dependence. Investigation into the human genetics of developmental hydrocephalus and choroid plexus hyperplasia, and the molecular physiology of the ion channels and transporters responsible for CSF secretion, might yield novel targets that could be exploited for pharmacotherapeutic intervention.

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Section: Hydrocephalus and Csf Productionmentioning

confidence: 99%

Cerebrospinal fluid hypersecretion in pediatric hydrocephalus

Karimy¹,

Durán²,

Hu³

et al. 2016

FOC

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“…Continuous EVD has certain complications, such as infection, technical obstructions, and recurrent hemorrhages, especially in SAH patients (10). In the current neurosurgical literature, there are sufficient data regarding the effects of continuous CSF drainage on serum Na + levels in children (11)(12)(13)(14)(15), but to the best of our knowledge, no report has been published regarding the same in case of adults.…”

Section: Introductionmentioning

confidence: 99%

Effects of External Ventricular Drainage on Serum Sodium Levels in Adult Neurosurgical Patients

Baran¹,

Kemerdere²,

Yuksel³

et al. 2018

Bezmialem Science

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Amaç: Hiponatremi; erişkin nöroşirurji hastalarında sık görülen elektrolit bozukluklarından birisidir. Çalışmamızın amacı, eksternal ventriküler drenajla BOS kaybı ile serum sodyum düzeyi arasındaki ilişkiyi ortaya koymaktır. Yöntemler: Çalışmada intrakranial patolojiler nedeniyle opere edilmiş ve eksternal ventriküler drenaj takılmış 67 hastanın (29 kadın, 38 erkek) serum sodyum düzeyleri retrospektif olarak çalışılmıştır. Hastaların serum sodyum düzeyleri; erken, orta ve geç dönem olmak üzere 3 farklı zaman dilimine ayrılmıştır. Bulgular: Ortalama BOS drenaj süresi 10±6,4 gün olarak hesaplanmıştır. 15 hastada BOS drenajı süresince hiponatremi gelişmiştir. Bu hastaların 13'ünde (%86,6) cerrahi öncesi sınırda hiponatremi bulunmaktaydı. Hipofiz makroadenomu olan bir hasta ile subaraknoid kanama tanısı ile takip edilen bir hastanın serum sodyumu postoperatif 3-7. günler arasında ortalama 129 mmol/L olarak hesaplanmıştır. BOS drenajı ile serum sodyum düzeyi arasında postoperative erken, orta veya geç dönemde anlamlı ilişki saptanmamıştır. Sonuç: BOS drenajı ile hiponatremi arasından anlamlı bir farklılık saptanmamış olması nedeniyle; EVD, hiponatremi yaratabilecek intrakranial patolojiler haricinde erişkin nöroşirurji hastalarında güvenle kullanılabilir.

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A Case of Difficult Management of Fluid-electrolyte Imbalance in Choroid Plexus Papilloma

Cited by 2 publications

References 10 publications

Cerebrospinal fluid hypersecretion in pediatric hydrocephalus

Cerebrospinal fluid hypersecretion in pediatric hydrocephalus

Effects of External Ventricular Drainage on Serum Sodium Levels in Adult Neurosurgical Patients

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