A Case of Cytomegalovirus Colitis that Developed during Chemotherapy for Advanced Gastric Cancer with Low Activity of Dihydropyrimidine Dehydrogenase

Kinoshita, Hiroyuki; Iwamoto, Hisao; Umano, Yasukazu; Tsubakihara, Hideaki; Sakata, Yoshifumi; Mori, Keiichiro

doi:10.3919/jjsa.76.1020

Cited by 2 publications

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“…In Japan, a total of 24 cases (including the present case) of severe adverse events were reported among patients with DPD deficiency who were treated with FPs, according to a search using PubMed and a domestic article search engine (3)(4)(5)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). The characteristics of these patients are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Severe Gastrointestinal Disorder Due to Capecitabine Associated with Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Literature Review

et al. 2022

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Dihydropyrimidine dehydrogenase (DPD) deficiency induces severe adverse events in patients receiving fluoropyrimidines. We encountered a 64-year-old DPD-deficient man with a severe capecitabine-related gastrointestinal disorder. He received capecitabine-containing chemotherapy after rectal cancer resection. During the first course of chemotherapy, he developed severe diarrhea, a fever, and hematochezia. Endoscopy revealed mucosal shedding with bleeding throughout the gastrointestinal tract. DPD deficiency was suspected because he developed many severe adverse events of capecitabine early and was finally confirmed based on the finding of a low DPD activity level in peripheral blood mononuclear cells. After one month of intensive care, hemostasis and mucosal healing were noted, although his gastrointestinal function did not improve, and he had persistent nutritional management issues.

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Section: Discussionmentioning

confidence: 99%

Severe Gastrointestinal Disorder Due to Capecitabine Associated with Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Literature Review

et al. 2022

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“…CMV enterocolitis is lethal because it can result in massive bleeding and gastrointestinal perforation [3]. To the best of our knowledge, only one case report of CMV enterocolitis with a partial DPD deficiency has been reported [4]. Here we report a thought-provoking case of CMV enterocolitis with partial DPD deficiency during neoadjuvant chemotherapy.…”

Section: Introductionmentioning

confidence: 89%

Cytomegalovirus enterocolitis in a patient with dihydropyrimidine dehydrogenase deficiency after capecitabine treatment: A case report

Inoue

Yano

Nakahara

et al. 2019

International Journal of Surgery Case Reports

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Highlights In the patients with DPD deficiency, advert events appear more rapidly than usual and can be lethal. Cytomegalovirus enterocolitis is likely to occur in the state of immunosuppression and lethal because of massive bleeding or perforation. Screening for DPD deficiency should be done, and genetic study can be effective screening for DPD deficiency.

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A Case of Cytomegalovirus Colitis that Developed during Chemotherapy for Advanced Gastric Cancer with Low Activity of Dihydropyrimidine Dehydrogenase

Cited by 2 publications

References 0 publications

Severe Gastrointestinal Disorder Due to Capecitabine Associated with Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Literature Review

Severe Gastrointestinal Disorder Due to Capecitabine Associated with Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Literature Review

Cytomegalovirus enterocolitis in a patient with dihydropyrimidine dehydrogenase deficiency after capecitabine treatment: A case report

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