A case of cutaneous protothecosis in a polyarteritis nodosa patient and review of cases reported in Japan

Okazaki, Chie; Wakusawa, Chihiro; Chikama, Rika; Murakami, Kazuhiro; Hitomi, Hideaki; Satoh, Kazuo; Makimura, Koichi; Hiruma, Masataro

doi:10.5070/d346h6w0qj

Cited by 7 publications

(2 citation statements)

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“…Cutaneous infections commonly arise in immunocompetent patients, while disseminated infections predominantly impact immunocompromised individuals. 1 , 11 , 12 Clinical management lacks a standardized protocol due to varying treatment efficacies. 13 , 14 In this context, we present a case of cutaneous protothecosis effectively cured through a three-month course of terbinafine treatment.…”

Section: Introductionmentioning

confidence: 99%

“…1,[7][8][9][10] This infection typically manifests in three primary forms: intra-cutaneous to subcutaneous nodules and plaques, olecranon bursitis, and systemic (disseminated) disease. 11 Notably, the skin emerges as the organ most frequently affected. Cutaneous infections commonly arise in immunocompetent patients, while disseminated infections predominantly impact immunocompromised individuals.…”

Section: Introductionmentioning

confidence: 99%

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Successful Treatment of Cutaneous Protothecosis Due to Prototheca wickerhamii with Terbinafine

Chen,

Gao,

et al. 2024

CCID

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Protothecosis, an infrequent human infection, is caused by achlorophyllic algae belonging to the genus Prototheca, particularly Prototheca wickerhamii. The skin stands as the most commonly affected organ. This report documents a case involving an 82-year-old male with Protothecosis. Histopathological analysis revealed granulomatous inflammation in the dermis, exhibiting necrotic features and hosting numerous non-budding spherical organisms. These organisms were positively stained using methenamine silver and periodic acid–Schiff stains, confirming identification as P. wickerhamii after validation through tissue culture and sequencing procedures. Initially, the patient received oral itraconazole at a dosage of 200 mg daily, accompanied by topical 1% naftifine-0.25% ketoconazole cream for a duration of 4 weeks, resulting in significant improvement. Subsequently, due to gastrointestinal discomfort presumably linked to itraconazole, terbinafine was administered. Over a span of 3 months, the patient received oral terbinafine at a dosage of 250 mg/day alongside the application of topical 1% naftifine-0.25% ketoconazole cream, leading to complete healing of the skin lesion, leaving behind a fibrotic scar.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Cutaneous Protothecosis Due to Prototheca wickerhamii with Terbinafine

Chen,

Gao,

et al. 2024

CCID

View full text Add to dashboard Cite

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Insect Bites and Infestations

Phung

Wright

Pourciau

et al. 2017

Pediatric Dermatopathology

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Successful treatment of cutaneous protothecosis with liposomal amphotericin and oral itraconazole

McMullan

Pollett

Biswas

et al. 2016

Medical Mycology Case Reports

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Protothecosis is a rare algal infection, affecting primarily immunocompromised hosts. Optimal management is unclear: in-vitro antimicrobial breakpoints are not established and therapeutic decisions are primarily based on case reports. We present a case of cutaneous Prototheca wickerhamii infection in an immunosuppressed 63 year old male, successfully treated with liposomal amphotericin and prolonged itraconazole. Inoculation may have been through frequent hot-tub use, highlighting hot-tub exposure as an infection risk for the immunocompromised host.

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A case of cutaneous protothecosis in a polyarteritis nodosa patient and review of cases reported in Japan

Cited by 7 publications

References 0 publications

Successful Treatment of Cutaneous Protothecosis Due to Prototheca wickerhamii with Terbinafine

Successful Treatment of Cutaneous Protothecosis Due to Prototheca wickerhamii with Terbinafine

Insect Bites and Infestations

Successful treatment of cutaneous protothecosis with liposomal amphotericin and oral itraconazole

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