A case of cutaneous plasmacytosis

Abstract

The present study reports a case of cutaneous plasmacytosis in a 51-year-old patient suffering from infiltrated erythema of the right lower lateral femur for 4–5 years and perioral and abdominal erythema for 1 year. Histopathological examination showed that dense mature plasma cell-dominant inflammatory cell infiltration appeared in the deep dermis and between part of the subcutaneous tissues and that there were small numbers of lymphocytes and polykaryocytes. Immunopathogenetic analysis showed that the infiltrating plasma cells were positive for CD79a and CD138. The patient was diagnosed with cutaneous plasmacytosis.

Primary cutaneous plasmacytosis successfully treated with topical corticosteroids and psoralen plus ultraviolet A: A case report

“…Immunohistochemical staining shows positive staining for CD138 and kappa or lambda light chains, confirming the plasma cell origin 12 . The presence of Russell bodies, which are eosinophilic intracytoplasmic inclusions, is a characteristic feature but not always present 13 . The isolated cutaneous involvement, however, is benign and persistent without spontaneous remission.…”

“… 12 The presence of Russell bodies, which are eosinophilic intracytoplasmic inclusions, is a characteristic feature but not always present. 13 The isolated cutaneous involvement, however, is benign and persistent without spontaneous remission. However, there have been a few reports of PCP turning into lymphoma, but the incidence of malignancy transformation has not been established.…”

Cutaneous Plasmacytosis treated with Tocilizumab: A Case Report and Review of the Literature

“…Most cases have no detectible inciting cause. One case of C/SP noted the presence of skin lesions in a prior area of leg trauma [2]. The geographic distribution of C/SP cases with the majority occurring in Japan lead to the speculation that a primary infectious or environmental cause is responsible [7].…”

“…There is no uniform, conclusive method for the treatment of cutaneous and systemic plasmacytosis [2]. Topical and systemic steroids, radiation, topical tacrolimus, pimecrolimus, antibiotics, systemic chemotherapy, and anti-CD20 antibody therapy have been tried in C/SP with inconsistent results [10,11,14,15].…”

“…Cutaneous and systemic plasmacytosis is an extraordinarily rare, reactive lymphoplasmacytic disorder characterized by mature plasma cell proliferation in the skin or organs [1,2]. Unlike multiple myeloma, the plasma cells in plasmacytosis do not showcase atypia and are therefore considered benign.…”