A Case of Cutaneous Malignant Fibrous Histiocytoma

Ichikawa, Eiko; Asano, Satoe; Okabe, Seigo; Itami, Makiko; Ohara, Kuniaki

doi:10.1111/j.1346-8138.1996.tb02647.x

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…2,5,7 It is rarely diagnosed before excision and anatomicopathological exam, and has an unfavorable prognostic in some cases. 1,4 This work reports the case of a young adult with cutaneous MFH and underscores the importance of the early diagnosis of this neoplasia.…”

Section: Introductionmentioning

confidence: 78%

“…A correct interpretation is important, since the prognostic and treatment vary significantly among those entities. 1,4 Ample excision is recommended, due to the high degree of local recurrence (approximately 44%) and metastasis, most commonly in the lungs (approximately 42% of cases). 2,5,7,8 The presence of metastasis is usually associated with a poor prognostic.…”

Section: Discussionmentioning

confidence: 99%

“…2,5,7 Dificilmente é diagnosticado antes da excisão e do exame anatomopatológico, e tem prognóstico reservado em alguns casos. 1,4 Este trabalho relata o caso de um adulto jovem com FHM cutâneo e reforça a importância do diagnóstico precoce dessa neoplasia.…”

Section: Introductionunclassified

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Fibro-histiocitoma maligno de extremidade: relato de caso

Siqueira¹,

Jardim²,

Bandeira³

et al. 2004

An. Bras. Dermatol.

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Fibro-histiocitoma maligno é o sarcoma de tecidos moles mais encontrado em jovens. Raramente confina-se com exclusividade à pele e ao subcutâneo. O diagnóstico, na maioria das vezes, só é feito após excisão e estudo da peça cirúrgica. É agressivo, apresentando alto grau de recorrência local e metástases. Este artigo relata o caso de um paciente jovem com fibro-histiocitoma maligno de extremidade.

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Section: Introductionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Fibro-histiocitoma maligno de extremidade: relato de caso

Siqueira¹,

Jardim²,

Bandeira³

et al. 2004

An. Bras. Dermatol.

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“…Most of them, however, arise from the retroperitoneal space [4, 9–11]. IMFH presenting as an ulcerative cutaneous lesion is extremely rare [8]. An elevated WBC is universally associated with this sarcoma; however, a leukemoid reaction with a leukocyte count above 50 K/mm 3 is extraordinary [7, 12].…”

Section: Discussionmentioning

confidence: 99%

“…IMFH associated with leukemoid reaction is rare and its presentation as a destructive cutaneous lesion is also unusual [8]. Here we discuss a case of an aggressive inflammatory MFH of dermal/epidermal origin located on the left upper extremity presenting with a severe leukemoid reaction.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature

Hurtado-Cordovi

Avezbakiyev

Frieri

et al. 2012

Case Reports in Medicine

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Malignant fibrous histiocytoma (MFH) is the most common sarcoma found in adults. We discuss a case of inflammatory MFH of dermal/epidermal origin presenting with a severe leukemoid reaction (LR). A 60 years old white male presented to hematology/oncology clinic complaining of mild shortness of breath on exertion. Past medical history was remarkable for removal of a left upper extremity necrotic mass 4.4 × 3 × 3 cm. Microscopy of the specimen showed clear surgical margin, and tumor cells restricted to the dermis without lymphovascular invasion. Immunohistochemestry was positive for CD 68 and CD 99. Chest x-ray was negative for metastatic disease. White blood cell count was 109.4 k/mm3with 24 k/mm3band neutrophils, and absolute neutrophil count of 69 k/mm3. CT scan of the thorax revealed numerous bilateral pulmonary nodules suspicious for metastasis. Based on these findings patient was diagnosed with metastatic cutaneous IMFH associated with a LR. Following review of medical literature, this appears to be the first reported case of inflammatory cutaneous MFH associated with LR. This histological variant is rare, and carries a poor prognosis. Thus, we would like to emphasize the need for investigating alternative therapies capable of improving the survival of these patients.

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Surgical excision margins for fibrohistiocytic tumors, including atypical fibroxanthoma and undifferentiated pleomorphic sarcoma: A probability model based on a systematic review

Jibbe¹,

Worley²,

Miller³

et al. 2022

Journal of the American Academy of Dermatology

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Background: Mohs micrographic surgery or wide local excision is the treatment of choice for fibrohistiocytic tumors with metastatic potential, including atypical fibroxanthoma (AFX) and cutaneous undifferentiated pleomorphic sarcoma (cUPS). Since margin clearance is the strongest predictor of clinical recurrence, improved recommendations for appropriate surgical margins help delineate uniform excision margins when intraoperative margin assessment is not available.Objective: To determine appropriate surgical wide local excision margins for AFX and cUPS.Methods: Literature search (Ovid MEDLINE, Embase, Web of Science, and Cochrane Library from inception to March 2020) to detect case-level data. Estimation of margins required using a mathematical model based on extracted cases without recurrences.Results: Probabilistic modeling based on 100 cases extracted from 37 studies showed peripheral clearance margin (ie, wide local excision margin) calculated to clear 95% of all tumors was 2 cm for AFX and 3 cm for cUPS. AFX tumors 1 cm or less required a margin of 1 cm.Limitations: Data were extracted from published cases.Conclusions: Atypical fibroxanthoma removed with at least a 2-cm peripheral excision margin is less likely to recur. Smaller tumors 1 cm or less can be treated with a more conservative margin. Margin-control surgical techniques are recommended to ensure complete removal while minimizing surgical morbidity.

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A Case of Cutaneous Malignant Fibrous Histiocytoma

Cited by 5 publications

References 11 publications

Fibro-histiocitoma maligno de extremidade: relato de caso

Fibro-histiocitoma maligno de extremidade: relato de caso

Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature

Surgical excision margins for fibrohistiocytic tumors, including atypical fibroxanthoma and undifferentiated pleomorphic sarcoma: A probability model based on a systematic review

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