A Case of Cutaneous <i>Mycobacterium Chelonae Abscessus</i> Infection in a Renal Transplant Patient

Endzweig, Carin H.; Strauss, Eric A.; Murphy, Francis; Rao, Babar

doi:10.1177/120347540100500107

Cited by 25 publications

(14 citation statements)

References 21 publications

(8 reference statements)

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“…In line with the literature (1, 5, 6), our experience with this case suggests that surgical intervention may be invaluable for the treatment of patients with M. chelonae infection. Surgery provides tissue specimens for accurate pathological diagnosis and antimicrobial susceptibility tests.…”

Section: Discussionsupporting

confidence: 85%

“…Although some authors have expressed concerns regarding the risk of introducing a foreign body into an actively infected spinal site, surgical treatment is indicated in patients with vertebral column deformities associated with instability and/or neurological compromise (1, 5–7). However, as there is poor adherence of Mycobacterium tuberculosis to the stainless steel and only little biofilm production, there are no cases of persistence or recurrence of infection after instrumentation surgery (8).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multifocal spinal and extra‐spinal Mycobacterium chelonae osteomyelitis in a renal transplant recipient

Korres¹,

Papagelopoulos²,

Zahos³

et al. 2007

Transplant Infectious Dis

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Only localized cases of Mycobacterium chelonae osteomyelitis have been reported. In this article, a 55-year-old immunosuppressed man with M. chelonae osteomyelitis and multiple spinal and extra-spinal involvement is presented. The patient had nodule-pustular skin lesions, spondylodiscitis at multiple levels, and osteolytic lesions at extra-spinal locations. Biopsy and cultures of the osseous lesions showed M. chelonae osteomyelitis. The patient started antimycobacterial chemotherapy with ciprofloxacin and clarithromycin. Progressive cervical kyphosis associated with anterior wedged deformity of the C5 vertebra and posterior C5-C6 spondylolisthesis resulted in compression of the spinal cord and neurological impairment. The patient underwent anterior decompression and C4-C6 arthrodesis using a titanium mesh cage and cervical plate. About 15 months after the initiation of chemotherapy and 5 months after surgery, the patient was pain free, with significant improvement of his neurological function. In the presence of immunosuppression, the physician should be alert for unusual or opportunistic pathogens of osteomyelitis. Long-term antimicrobial chemotherapy and surgical intervention is the cornerstone of successful treatment of multifocal bone M. chelonae infection.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Multifocal spinal and extra‐spinal Mycobacterium chelonae osteomyelitis in a renal transplant recipient

Korres¹,

Papagelopoulos²,

Zahos³

et al. 2007

Transplant Infectious Dis

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“…Deeper infections may occur following trauma or in association with chronic disease or immunosuppression (1,2). Subcutaneous infections have been reported in liver, heart, lung, and kidney transplant patients (3–8). A recent retrospective study of 45 patients with M. abscessus infection identified 20% as solid organ transplant recipients and an additional 40% on immunosuppressive medications for other reasons (2).…”

Section: Discussionmentioning

confidence: 99%

Erythematous Crusted Plaques in a Pediatric Transplant Recipient

Mason

Kress

2008

Pediatric Dermatology

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A 17-year-old white boy was seen at the outpatient clinic of the Discipline of Stomatology, Sa˜o Jose´dos Campos Dental School-UNESP, complaining of the presence of nodules in the mouth, nasal, and palpebral mucosae, unaltered since birth. Clinical examination revealed painless mucosal nodules of variables sizes on the lips, buccal mucosa, and lateral borders of the tongue and palate, whose color was similar to that of the adjacent mucosa (Fig. 1). Papules were also present in the nasal mucosa and on the left lower eyelid (Fig. 2). The lips had been submitted to cosmetic surgery years before but without histopathological analysis of the removed material. Physically, the patient exhibited a tall stature and evidently elongated upper and lower limbs, in addition to manifestations of scoliosis. The patient was otherwise apparently well with no systemic symptoms and had no other dermatologic lesions.A biopsy was taken from one of the nodules located on the left lateral border of the tongue and sent for histological analysis (Fig. 3).

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“…Bei nierentransplantierten Patienten treten Infektionen mit M. chelonae (Fall 3) häufiger auf, wobei trotz entsprechender Antibiose eine hohe Rezidivgefahr besteht [7].Klinisch zeigen sich oft abszedierende Knoten; bei immunsupprimierten Patienten sind auch disseminierte Infektionen beschrieben [2].…”

Section: Cutaneous Atypical Mycobacterioses · Antibiotic Therapyunclassified

“…Gegen die üblichen Tuberkulostatika liegt quasi immer eine Resistenz vor [18]. Clarithromycin (2-mal 500 mg/Tag) gilt als Mittel der Wahl [7,9]. Bei unserer Patientin (Fall 3) hatte Clarithromycin zur Heilung geführt, ein Rezidiv trat nicht auf.…”

Section: Cutaneous Atypical Mycobacterioses · Antibiotic Therapyunclassified

Sporotrichoide atypische Mykobakterien

Bormann

2004

Der Hautarzt

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Sporotrichoid forms of atypical mycobacterial infections usually do not show a tendency to spontaneous healing. The therapy of choice in such cases is systemic antibiotics. We report three cases of sporotrichoid atypical mycobacterial infections of the skin which healed completely under long-term monotherapy with modern antibiotics (levofloxacin, clarithromycin, minocycline). We recommend confirming the diagnosis by means of culture, followed by monotherapy with low side-effect antibiotics, based on sensitivity studies. If pathogen proof is obtained by PCR, antibiotic therapy should be based on the known sensitivity of the pathogen in question.

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A Case of Cutaneous Mycobacterium Chelonae Abscessus Infection in a Renal Transplant Patient

Cited by 25 publications

References 21 publications

Multifocal spinal and extra‐spinal Mycobacterium chelonae osteomyelitis in a renal transplant recipient

Multifocal spinal and extra‐spinal Mycobacterium chelonae osteomyelitis in a renal transplant recipient

Erythematous Crusted Plaques in a Pediatric Transplant Recipient

Sporotrichoide atypische Mykobakterien

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