A case of contact dermatitis caused by a polyurethane hot melt adhesive

Ito-Watanabe, Mana; Hayama, Koremasa; Fujita, Hideki; Sasaki, Koichi; Numata, Masahiro; Terada, Tadashi

doi:10.1111/cod.13340

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…The polyurethane elastic band on the N95 was identified as the possible causative agent, as it was the only material that was different between the two masks. We completed a literature review for hypersensitivity and anaphylaxis to polyurethane, noting that isocyanates, which are used as hardening agents in the production of polyurethane, have been associated with allergic reactions and contact dermatitis 4 7 10. To identify the specific isocyanate implicated, we performed isocyanate patch testing (isocyanate series patch from Chemotechnique MB diagnostics, Sweden) to seven excipients and a negative control (table 1).…”

Section: Investigationsmentioning

confidence: 99%

Severe allergic systemic reaction to personal protective equipment during the COVID-19 pandemic

2023

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Our case describes a hospital worker who suffered a severe reaction to personal protective equipment (PPE) during the COVID-19 pandemic. After researching the excipient list of her PPE and completing a literature review, we postulated that isocyanates used in the production of the polyurethane band of the N95 mask was the cause for her reaction. In the absence of standardised testing, we tested this hypothesis by replicating her reaction to PPE by using a commercially available isocyanate patch, identifying diphenylmethane-4, 4-diisocyanate as the culprit agent.We recommended caution in the use of polyurethane containing N95 masks- for people reporting allergic reaction- and testing for sensitivity for polyurethane. The patient was able to tolerate non-polyurethane containing standard surgical masks, providing an option for PPE in some clinical circumstances. Since avoiding N95 masks, she has not had any further reactions.

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Section: Investigationsmentioning

confidence: 99%

Severe allergic systemic reaction to personal protective equipment during the COVID-19 pandemic

2023

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Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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A case of contact dermatitis caused by a polyurethane hot melt adhesive

Cited by 2 publications

References 3 publications

Severe allergic systemic reaction to personal protective equipment during the COVID-19 pandemic

Severe allergic systemic reaction to personal protective equipment during the COVID-19 pandemic

Contact Allergy—Emerging Allergens and Public Health Impact

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