A case of congenital scleredema

Ets transcription factors bind and transactivate the core promoter of the von Willebrand factor gene

“…The nucleotide recognition sequence of the Ets class of DNA-binding protein inside EBS1 sequence is required for the function of the 760 to +19 core promoter Ets protein binding sites are about ten nucleotides long and contain the central core motif GGA(A/T)¯anked by degenerate but non random 5' and 3' sequences which contribute to the DNA binding selectivity of members of the family Wang et al, 1992). To analyse the importance of nucleotides situated inside or¯anking the GGAA core of the functional EBS1 sequence and to con®rm the involvement of a DNA-binding protein of the Ets class family, a series of mutations was performed in plasmid pGvWCAT760/+19.…”

“…Several studies have suggested that the sequences anking the GGAA/T core of Ets binding sites determine the binding speci®city and the transcriptional activation properties of di erent members of the family (Wang et al, 1992;Urness and Thummel, 1990;Shore et al, 1996;Reddy and Rao, 1991). Mutagenesis of individual nucleotides in the GGA sequence of EBS1 abolished the promoter activity.…”

Dark Energy

“…Therefore, most researchers have chosen to study dark energy by constraining w from observations. However, in a series of works [515,719,720,721,722,723,724], Wang and collaborators argued that, due to the smearing effect [712] arising from the multiple integrals relating w(z) to the luminosity distance of SN d L (z), it is difficult to constrain w using the SN data [711]. On the contrary, since using the dark energy density ρ de can minimize the smearing effect by removing one integral, ρ de can be constrained more tightly than w given the same observational data (see Fig.…”

“…It should be mentioned that there was a debate about the reliability of this ansatz [765,766]. Another interesting polynomial fit is the polynomial interpolation, which was proposed by Wang [515,345,719,720,721,722,723,724]. It choose different redshift points z i = i * z max /n(i = 1, 2, · · · , n), and interpolate f(z) by using its own values at these redshift points.…”

Scrotal Calcinosis: A Case Report And Review Of Literature

“…Calcified nodules not only increase in number, but also become larger throughout life, and they may encircle almost entire scrotum. It is an exception that the lesions undergo spontaneous regression ; once reported by Hwang et al (6). While the lesions are initially skin-colored, they become yellowish as they grow.…”