A case of congenital herpes simplex virus infection diagnosed at 8 months of age

Yamamoto, Shigeo; Nagamori, Tsunehisa; Komatsu, Shigetsuna; Shirai, Masaru; Suzutani, Tatsuo; Oki, Junichi

doi:10.1016/j.braindev.2020.01.003

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…As previously reported, primary infection in late pregnancy increases the risk of vertical transmission [13]. The increased rates of fetal loss and the neurodevelopmental disorders regarding fetal neurons and neuronal precursors following HSV infection are associated with poor prognosis [13,15]. As evidenced by the literature, there are inconclusive results concerning the mechanism responsible for fetus infection by HSV.…”

Section: Introductionmentioning

confidence: 97%

Congenital Herpes Simplex Virus: A Histopathological View of the Placenta

Deftereou¹,

Trypidi²,

Alexiadi³

et al. 2022

Cureus

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Congenital Herpes simplex virus (HSV) infection is considered a common pregnancy pathology that is not always easy to diagnose. This study aimed to present the spectrum of placental histopathological lesions in pregnancies complicated by HSV infection. MEDLINE and Google Scholar databases were searched using the keywords "HSV" and "placental histopathology" up to June 20, 2022. Study inclusion required presenting placental histopathological anomalies in pregnant women diagnosed with HSV infection antenatally, during labor, or postnatally. Herein, we briefly present placental pathogenesis conditions, which have been correlated with congenital HSV infection, providing clinicians with a short review describing herpetic placental pathology.

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Section: Introductionmentioning

confidence: 97%

Congenital Herpes Simplex Virus: A Histopathological View of the Placenta

Deftereou¹,

Trypidi²,

Alexiadi³

et al. 2022

Cureus

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Hearing Loss in Neonates Exposed to Herpes Simplex Virus

Bayhan,

Arısoy,

Correa

2023

Comprehensive ENT

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Diagnostic Utility of Preserved Dried Umbilical Cord Polymerase Chain Reaction in Intrauterine Herpes Simplex Virus Infection: A Case Report and Literature Review

Tsuda,

Matsushige,

Inoue

et al. 2024

Neonatology

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Introduction: Intrauterine herpes simplex virus (HSV) infection is uncommon and challenging to diagnose, requiring detection of HSV in skin lesions within 48 h post-birth. Case Presentation: A preterm female infant presented with the typical triad of blisters, microcephaly, and chorioretinitis, but the initial diagnostic approach was elusive due to negative results for TORCH pathogens from vesicles/serum. Referred at 7 months for developmental delay and epilepsy, her brain imaging showed calcification and cortical dysplasia. Polymerase chain reaction (PCR) of her preserved dried umbilical cord detected HSV-2 DNA, diagnosing intrauterine HSV infection. HSV-2 was later found in relapsed blisters at 8 months but not in cerebrospinal fluid or brain tissue. A literature review identified 104 congenital/intrauterine HSV cases; 28.8% presented the typical triad, and 50% were diagnosed using specimens collected 48 h post-birth. Conclusion: This case marks the first retrospective diagnosis of intrauterine HSV infection via PCR on preserved umbilical cord, underscoring its diagnostic value.

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A case of congenital herpes simplex virus infection diagnosed at 8 months of age

Cited by 3 publications

References 11 publications

Congenital Herpes Simplex Virus: A Histopathological View of the Placenta

Congenital Herpes Simplex Virus: A Histopathological View of the Placenta

Hearing Loss in Neonates Exposed to Herpes Simplex Virus

Diagnostic Utility of Preserved Dried Umbilical Cord Polymerase Chain Reaction in Intrauterine Herpes Simplex Virus Infection: A Case Report and Literature Review

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A case of congenital herpes simplex virus infection diagnosed at 8 months of age

Cited by 3 publications

References 11 publications

Congenital Herpes Simplex Virus: A Histopathological View of the Placenta

Congenital Herpes Simplex Virus: A Histopathological View of the Placenta

Hearing Loss in Neonates Exposed to Herpes Simplex Virus

Diagnostic Utility of Preserved Dried Umbilical Cord Polymerase Chain Reaction in Intrauterine Herpes Simplex Virus Infection: A Case Report and Literature Review

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A case of congenital herpes simplex virus infection diagnosed at 8 months of age