A Case of Concurrent Psoriasis and Hidradenitis Suppurativa Successfully Treated with Tildrakizumab

Abstract

Introduction Plaque psoriasis and hidradenitis suppurativa are chronic inflammatory skin conditions with common pathogenetic pathways. Methods We report the case of a 38-year-old man with 15-year history of psoriasis and hidradenitis suppurativa successfully treated with tildrakizumab for both conditions. After treatment failure to adalimumab, secukinumab, and guselkumab, tildrakizumab therapy was initiated and resulted in complete remission of psoriasis and the achievement of hidradenitis suppurativa clinical response after 40 weeks, without reporting adverse events. These responses were maintained at week 52. Conclusion Tildrakizumab may be an effective and safe therapeutic option for concomitant psoriasis and hidradenitis suppurativa.

Guselkumab, Risankizumab, and Tildrakizumab in the Management of Hidradenitis Suppurativa: A Review of Existing Trials and Real-Life Data

“…The results were confirmed at week 52, and the authors reported no side effects. 22 The other case described in the literature concerns a case of a 50-year-old patient affected by PASH syndrome who had had a significant worsening of HS; 23 the patient had practiced in the past with only limited benefit unspecified antibiotic therapy and adalimumab (interrupted for ineffectiveness); therefore, the authors report having started treatment with tildrakizumab. At baseline, the patient had an abscess and nodule count of 45, DLQI score of 26, and visual analog scale (VAS) pain score of 10 was reported.…”