A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes

Tan, Char Loo; Raju, Gangaraju Changal; Petersson, Fredrik

doi:10.4081/rt.2011.e16

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…Nonetheless, coexisting non-salivary gland neoplasms with WT are not reported in the literature within the same parotid gland except for one case of WT with LCH. Tan et al [ 11 ] reported a synchronous WT and LCH in a 50-year-old man, which presented as painless right parotid swelling with a sudden increase in size and a recent inguinal lump. His blood count showed leukocytosis and eosinophilia.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the patient’s tumor also exhibited necrosis, eosinophilic abscesses, and granulomatous reaction within the intra-parotid lymph nodes, which raised KD as a differential diagnosis. However, there was no significant fibrosis, follicular hyperplasia, or other characteristic features of KD [ 11 ]. The patient underwent parotidectomy, with no evidence of recurrence after 4 months of follow-up [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, there was no significant fibrosis, follicular hyperplasia, or other characteristic features of KD [ 11 ]. The patient underwent parotidectomy, with no evidence of recurrence after 4 months of follow-up [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Synchronous salivary gland neoplasms are seen most commonly with WT and usually occur bilaterally [ 10 ]. Only one rare case of parotid WT coexisting with Langerhans cell histiocytosis (LCH) was reported in the same gland [ 11 ]. In this report, we describe a case of concurrent WT and KD in the parotid gland, the first that we are aware of in the English literature, and describe the clinicopathological features of the case.…”

Section: Introductionmentioning

confidence: 99%

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Concurrent Warthin tumor and Kimura disease: a case report

et al. 2023

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Background Warthin tumor (WT) is a common benign salivary tumor of the parotid gland. Clinically, it occurs in men in their fifth to seventh decades who typically smoke cigarettes. WTs have been reported with different head and neck neoplasms and other salivary gland tumors within the same or another salivary gland. Kimura disease (KD) is a rare chronic inflammatory disease with unknown etiology affecting young to middle-aged Asian men. KD presents as an asymptomatic nodule in the head and neck area, with regional lymphadenopathy and salivary gland involvement. Case presentation A 64-year-old Arabic man presented with a 10-year history of an asymptomatic swelling of the left face. Computed tomography showed a well-defined, multicystic mass with heterogeneous enhancement. The resected mass was composed of two distinct components. There was a well-demarcated proliferation of papillary and cystic oncocytic epithelium with lymphoid stroma, consistent with WT. Some areas exhibited sclerotic fibrosis, with multiple lymphoid follicles showing folliculolysis, follicular hyperplasia, and eosinophilic infiltrate. The patient’s immunoglobulin E level serum was elevated, confirming a coexisting KD. The patient underwent a left superficial parotidectomy, with no recurrence at a 30-month follow-up. Conclusion This report describes the first concurrent case of WT and KD in the parotid gland.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Concurrent Warthin tumor and Kimura disease: a case report

et al. 2023

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“…Langerhans cells could be seen in association with other neoplasms as a concurrent neoplasm or just as passenger inflammatory cells. To date, two reported cases of LCH in association with the salivary gland [ 16 , 17 ]. We herein report a case of carcinosarcoma ex pleomorphic adenoma associated with Langerhans cell histiocytosis in a 75-year-old male.…”

Section: Introductionmentioning

confidence: 99%

A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland

AlMadan¹,

Sulaiman²,

Almayouf³

et al. 2023

Cureus

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Carcinosarcoma ex pleomorphic adenoma is a rare malignant neoplasm, with most cases reported in the parotid gland. We herein report a case of a 75-year-old male referred to our hospital with a long-standing right parotid lesion that was treated in an outside hospital by a superficial parotidectomy. The patient reported a painful, rapidly enlarging mass following the excision. Histopathological examination showed the proliferation of malignant epithelial and mesenchymal elements with a solid sheet of Langerhans cells admixed with eosinophils. The Langerhans cells were reactive to CD1a and BRAF; hence, a diagnosis of carcinosarcoma ex pleomorphic adenoma with Langerhans cell histiocytosis was given. Complete clinical and radiographic workup showed no other organ involvement. The patient underwent total parotidectomy with adjuvant chemoradiation; however, the tumor progressed and showed lung metastasis. We herein report the first case of a concurrent Langerhans cell histiocytosis with associated carcinosarcoma ex pleomorphic adenoma.

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