A Case of CNS Actinomycosis: Rarer than Rare!

Limaye, Harshad S; Hinduja, Anupa R A; Verma, Mansi; Oak, Pradyumna

doi:10.4103/0028-3886.314572

Cited by 1 publication

(2 citation statements)

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“…2 Actinomycosis of CNS can present with hemiparesis, focal or generalised seizures, headache and other features of raised intracranial pressure and spaceoccupying effects. [4][5][6][7][8][9] Leucocytosis may be detected on routine investigations. 4 5 9 Other acute phase reactants may be normal or mildly elevated.…”

Section: Discussionmentioning

confidence: 99%

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Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge

et al. 2022

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Central nervous system (CNS) involvement by actinomycosis is rare, seen in 2%–3% cases. It mostly spreads to CNS by haematogenous route from a distant primary site such as oral cavity, lung, abdomen or pelvis. Direct CNS extension can also occur. It mostly presents as brain abscess, meningoencephalitis, actinomycetoma, subdural empyema and epidural abscess. We report one case of extensive actinomycosis having intra and extraparenchymal CNS, spinal canal, retropharyngeal and mediastinal involvement. Due to such widespread extension and involvement of vital areas, complete surgical debulking was not possible. In addition to therapeutic resistance to conventional antibiotics, repetitive negative cultures posed significant difficulty in the case management.

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Section: Discussionmentioning

confidence: 99%

“…Frontotemporal lobes are most frequently involved by brain abscess 2. Actinomycosis of CNS can present with hemiparesis, focal or generalised seizures, headache and other features of raised intracranial pressure and space-occupying effects 4–9. Leucocytosis may be detected on routine investigations 4 5 9.…”

Section: Discussionmentioning

confidence: 99%