A case of chronic necrotizing pulmonary aspergillosis due toAspergillus nidulans

Mizuki, Masami; Chikuba, Keiko; Tanaka, Kouichi

doi:10.1007/bf01103012

Cited by 14 publications

(6 citation statements)

References 18 publications

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“…A. nidulans is strongly associated with osteomyelitis in patients with chronic granulomatous disease (CGD) [22,23], but otherwise remains an infrequent cause of cerebral [24] and pulmonary [25] aspergillosis. Here we report invasive A. nidulans infection in two non-CGD patients.…”

Section: Discussionmentioning

confidence: 99%

Culture-positive invasive aspergillosis in a medical center in Taiwan, 2000–2009

Hsiue

Chang

et al. 2011

Eur J Clin Microbiol Infect Dis

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We reviewed 776 patients who were culture positive for Aspergillus species at the hospital from 2000 to 2009. The isolates were collected for species identification by oligonucleotide hybridization and sequence analysis. A total of 96 cases of proven or probable IA were identified according to published criteria. The incidence of IA has increased significantly during the study period. Aspergillus fumigatus and A. flavus (41.7% each) were equally prevalent causative species. IA due to unusual species including A. nidulans (n=2), A. versicolor (n=2), and A. tubingensis (n=1) were also found. Among patients with IA, 55.2% had hematological disorder, 19.8% had underlying lung disorder, and 10.4% had autoimmune disease. The isolates species (P<0.001) and underlying disease (P<0.001) significantly affect the association of a positive culture with invasive disease. The overall mortality at three months was 62.5%, which remained stable throughout the study period. Multivariate analysis identified prior steroid use (P=0.007) as a significant risk factor for death, while surgery (P=0.030) and voriconazole (P=0.012) had protective effects. In conclusion, autoimmune disorders and underlying pulmonary diseases should also be considered as important predisposing factors of IA. Further emphasis on surgery and voriconazole in the management of IA might be beneficial.

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Section: Discussionmentioning

confidence: 99%

Culture-positive invasive aspergillosis in a medical center in Taiwan, 2000–2009

Hsiue

Chang

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…Binder et al proposed the concept that chronic necrotizing pulmonary aspergillosis is the chronic form of invasive pulmonary aspergillosis (1). Whichof these forms occur maybedependent on the reciprocal action of the host immune system and the pathogenicity of aspergillus species (1)(2)(3). In this case, the time from hospital visit to death was one year.…”

Section: Discussionmentioning

confidence: 99%

Invasive Pulmonary Aspergillosis with Thrombosis in the Left Atrium.

et al. 2001

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Wereport a female patient with left atrial wall invasion from pulmonary aspergillosis. She had been treated for diabetes mellitus. Pulmonary aspergillosis extended to the left atrial wall via the left pulmonary vein and formed a polypoid lesion in the left atrium. The polypoid lesion was composed of thrombus, and the thrombus increased in size to become large, and it showed invagination into the mitral valve during diastole. Weconsidered that the thrombus was formed on the injured endocardium. Severe invasive aspergillosis thus could occur in a mild systemic immunocompromisedhost. (Internal Medicine 40: 250-254, 2001)

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“…9 Additionally, the lower airway is not immune to this pathogen; a rare case of chronic necrotizing pulmonary aspergillosis was attributed to A. nidulans. 10 Morbidity/mortality rates among different Aspergillus species have not been studied well, given the rarity of A. nidulans as a cause of invasive and non-invasive sinusitis. One study included cases diagnosed to have chronic granulomatous disease (CGD) with osteomyelitis due to A. nidulans and compared them with cases caused by A. fumigatus.…”

Section: Discussionmentioning

confidence: 99%

A case report of rare fungal pathogens causing recurrent allergic fungal rhinosinusitis and literature review

Alroqi

2021

Science Progress

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Allergic fungal rhinosinusitis has been well characterized clinically. We report about a patient diagnosed with allergic fungal rhinosinusitis. Nasal cultures revealed a rare fungal pathogen, Aspergillus nidulans. At the time of initial presentation and later recurrence, another rare fungus was found. Trichoderma are unique and have been described in detail. This report describes unique pathogens causing allergic fungal rhinosinusitis. The relevant literature demonstrates the potential morbidity and mortality due to infections from such organisms, indicating the need for physicians to manage and treat this condition carefully to prevent potential complications.

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A case of chronic necrotizing pulmonary aspergillosis due toAspergillus nidulans

Cited by 14 publications

References 18 publications

Culture-positive invasive aspergillosis in a medical center in Taiwan, 2000–2009

Culture-positive invasive aspergillosis in a medical center in Taiwan, 2000–2009

Invasive Pulmonary Aspergillosis with Thrombosis in the Left Atrium.

A case report of rare fungal pathogens causing recurrent allergic fungal rhinosinusitis and literature review

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