A case of choriocarcinoma with concurrent rare presentations: Spontaneous uterine rupture and extensive thoracic spine metastases

Hashemi, Seyed Mehdi; Derakhshandi, Hajar; Fazeli, Seyed Amirhossein; Sistani, Sharareh Sanei; Amirifard, Hamed

doi:10.3109/01443615.2015.1127904

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…[6,7] Table 1 presents all cases of reported choriocarcinoma metastases to the spine up to date. [2,[6][7][8][9][10][11][12] So far, clinically, limited cases of choriocarcinoma spine metastases have been reported. Choriocarcinoma is a chemosensitive malignant cancer with a good prognosis, even in advanced stages.…”

Section: Discussionmentioning

confidence: 99%

“…According to the reported cases, most patients with a systematic treatment based on multidrug chemotherapy combining radiotherapy and surgery ultimately ended up with death. [2,[6][7][8][9][10][11][12] Some characteristic markers of the choriocarcinoma are helpful for the accurate diagnosis, Kavanagh proposed a correlation with the upregulated levels of vascular endothelial growth factor, thought to be involved in the development of trophoblastic disease. [13] The typical imaging findings are dependent on the site of metastasis, which is associated with extensive bleeding.…”

Section: Discussionmentioning

confidence: 99%

“…[5] In this case presenting no vaginal bleeding, but spinal oppressive symptoms, the spine metastases were very rare compares to common lung metastases. [6,7] Table 1 presents all cases of reported choriocarcinoma metastases to the spine up to date. [2,[6][7][8][9][10][11][12] So far, clinically, limited cases of choriocarcinoma spine metastases have been reported.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Choriocarcinoma masquerading as lumbar spinal tumor: Case report and literature review

Liu

Sun

et al. 2023

Medicine

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Rationale: Choriocarcinoma is a highly invasive gestational trophoblastic neoplasm, usually metastasis to lung and brain, but occurrence of choriocarcinoma following spontaneous abortion presenting as a vertebral tumor is extremely rare, to the best of our knowledge. Because of the poor diagnosis and high malignancy, the low progression-free survival follows up. Patient concerns: We here are reporting a case of choriocarcinoma that presented with vertebral tumor induced paralysis of limbs and incontinence of urine. Diagnosis: Combined with the childbearing history, high β-human chorionic gonadotrophinin levels, and imaging examination, a clinical diagnosis was made exactly. Till the pathological results after the operation of lumbar spinal canal tumorectomy, the diagnosis was exactly clear. Interventions: After performing the laminectomy, the fierce bleeding follows up, just did the temporary limited decompression. Because of the vertebral artery embolization, lumbar spinal canal tumorectomy, spinal canal and root canal decompression, subdural decompression and hematoma removal were performed. Outcomes: After performing the operation and chemotherapy timely and positively, the patient lost consciousness and died due to the pulmonary embolism at last. Lessons: This is the first case report describing choriocarcinoma with metastases to the spine amongst Chinese population as well. Early metastasis is one of the marked tendencies of choriocarcinoma, but spine metastasis and the related spinal oppressional symptoms were found instead of vaginal bleeding in this case, which is indeed rare.

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