A case of childhood sarcoidosis

Hunt, Steven J.; Wakelin, S. H.; Walters, Stephen; O'Toole, EA; Philips, Wannes; Hardman, Catherine

doi:10.1046/j.1365-2230.2002.01047.x

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…30 Sarcoidosis of the knees is frequently associated with erythema nodosum. [36][37][38][39] There are reports of its occurrence in monozygotic twins. 35 Sarcoidosis predominantly affects adults; skin lesions are rarely seen in children.…”

Section: Sarcoidosismentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Section: Sarcoidosismentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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“…2 The cause of this condition is unknown; an antigenic stimulus and a genetic predisposition are required to produce granulomatous inflammation. 3 Sarcoidosis is characterized by multiple granulomas, which are defined as compact collections of macrophages and epitheloid cells encircled by lymphocytes. 4 The presence of CD4 T-cells interacting with antigen-presenting cells seems to initiate the formation of granulomas.…”

Section: Discussionmentioning

confidence: 99%

Icthyosiform Eruption and Swollen Articulations in a Girl

Balma-Mena

Cammisuli

2010

Clin Pediatr (Phila)

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We report the case of a 2½-year-old girl who was diagnosed with atopic dermatitis at 5 months of age. She received treatment with hydrocortisone cream 1% and prednicarbate cream without improvement. At the age of 17 months, she developed swollen painful joints and photophobia. Joint involvement included the wrists, knees, ankles, and elbows. Her past medical history was otherwise negative, with a normal pregnancy and delivery. The child's mother was a hepatitis B carrier.The patient was initially assessed by the rheumatology department because of her polyarthritis and difficulty in ambulating because of pain. On physical examination, she presented with boggy articulations, tenosynovitis, and dactylitis of multiple joints, including the knees, wrists, interphalangeals, and shoulders.She presented to our dermatology clinic with a generalized icthyosiform erythrodermic eruption with infiltrated erythematous papules on her extremities, face, abdomen, and palms (Figure 1). Ophthalmology examination showed granulomatous uveitis, and treatment was started with atropine and prednisone eye drops 3 times a day.Laboratory investigations showed a C-reactive protein level of 28 mg/L, a white cell count of 16 000 10 9 /L, a hemoglobin level of 102 mg/L, and platelets at 662 000 10 9 /L. Immunoglobulins, C3, and C4 were normal. Electrolytes, including calcium, liver, and renal function tests, were normal. Antinuclear antibodies and rheumatoid factor were negative. Angiotensinconverting enzyme (ACE) levels were elevated at 87 (normal, 5-83 U/L). Serology for hepatitis B and tuberculin skin tests were negative.Radiological investigations revealed a normal chest film, but hand X rays showed soft tissue swelling in the wrists and in multiple interphalangeal joints. A skin biopsy showed parakeratosis, with epitheloid infiltrates, histiocytes, and mononuclear inflammatory cells forming noncaseating granulomas. A few small granulomas were present in the subcutaneous adipose tissue. No vasculitis was seen, and the cultures were negative (Figure 2).The clinical findings and histopathology were suggestive of sarcoidosis, and the patient started treatment

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“…The most common extraintestinal sites include eyes, skin, joints, and liver. A pattern of multisystemic chronic inflammation may also occur in sarcoidosis, an inflammatory disorder of unknown aetiology identifiable by the formation of confluent noncaseating granulomas [6]. Although apparently distinct, both diseases seem to share some similar immunologic pathways [5,12].…”

Section: Introductionmentioning

confidence: 99%

Juvenile sarcoidosis presenting as Crohn’s Disease

et al. 2006

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A 12-year-old Turkish girl suffered from abdominal pain located in the right lower abdomen for 3 weeks. Ultrasound revealed palisade-like swelling of the mucosa in the ileum. Gastrointestinal biopsy showed incipient granulomas in the stomach and moderate fibrosis of the terminal ileum. Subsequently, bilateral hilar adenopathy and an abnormal level of serum angiotensin-converting enzyme were detected. The relevance of paediatric sarcoidosis mimicking Crohn's disease is discussed.

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A case of childhood sarcoidosis

Cited by 7 publications

References 7 publications

The granulomatous reaction pattern

The granulomatous reaction pattern

Icthyosiform Eruption and Swollen Articulations in a Girl

Juvenile sarcoidosis presenting as Crohn’s Disease

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