A case of cerebellar medulloblastoma with a single chromosome abnormality

Stratton, M. R.; Jl, Darling; Cooper, Christopher S.; Reeves, Brian

doi:10.1016/0165-4608(91)90120-j

Cited by 15 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have described the cytogenetic findings in our series of 20 P N E T s and have reviewed 53 pediatric PNETs/medulloblastomas reported in the literature, where detailed karyotypes were adequately described (Bigner et al, 1988b;Griffin et al, 1988;Biegel et al, 1989;Callen et al, 1989;Sawyer et al, 1991a;Stratton et al, 1991;Karnes et al, 1992). No abnormal clones were found in eight (15.1%) of these reviewed cases.…”

Section: Discussionmentioning

confidence: 89%

Chromosome analysis of brain tumors in childhood

Fujii

Hongo

Hayashi

1994

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

We performed a chromosome analysis of 26 pediatric brain tumors, including 20 primitive neuroectodermal tumors (PNETs). 5 astrocytomas, and 1 immature teratoma. Specimens were treated with collagenase, placed in overnight or short-term cultures, and harvested for chromosome analysis. Numerical and/or structural abnormalities were noted in 14 of the 20 PNETs and 4 of the 5 astrocytomas. In 13 PNETs, so-called medulloblastoma in the cerebellum, an i(17q) was the most frequent structural abnormality, accounting for 30% (4/13). Double minute chromosomes (dmin) were observed in one tumor. Near-diploidy was demonstrated in three of these PNETs, hyperdiploidy in three, and near-tetraploidy in three. We could not find any correlation of these cytogenetic findings with the prognosis. In the remaining seven PNETs other than medulloblastoma, the karyotypes of five PNETs demonstrated a variety of numerical and structural abnormalities. As to the astrocytomas, losses of chromosomes 7 and 9 with dmin were observed in two, and structural abnormalities of chromosomes 1 and 17 were also observed in two tumors. In our limited cases, however, we could not find the same chromosome abnormalities that are well known in adult astrocytomas. A congenital immature teratoma showed hyperdiploidy with increased numbers of chromosomes 3, 6, and 12. We conclude that i(17q) is an important chromosome abnormality in medulloblastomas, and that the oncogenesis of pediatric astrocytomas might be different cytogenetically from that of adult astrocytomas.

show abstract

Section: Discussionmentioning

confidence: 89%

Chromosome analysis of brain tumors in childhood

Fujii

Hongo

Hayashi

1994

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

show abstract

“…We have confirmed our previous findings that abnormalities of chromosomes 6, 7, and 11 are frequent changes in PNETs. Loss of all or part of chromosome 6 has been noted as a single change in several PNETs (Griffin et al, 1988;Biegel et al, 1989;Stratton et al, 1991), suggesting that it is another primary cytogenetic event. Loss of heterozygosity studies have confirmed the deletion of chromosome arm 6q (Raffel et al, 1990) in some PNETs.…”

Section: Discussionmentioning

confidence: 99%

Isochromosome 17q demonstrated by interphase fluorescence in situ hybridization in primitive neuroectodermal tumors of the central nervous system

Biegel

Rorke

Janss

et al. 1995

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

We previously reported an i(17q) as a non-random finding in childhood primitive neuroectodermal tumors (PNETs) of the central nervous system. In the present study, we describe a two-color interphase fluorescence in situ hybridization (FISH) assay for detection of chromosome 17 abnormalities in tumors. Thirty-four PNETs were analyzed by FISH with a series of chromosome 17-specific probes which map to 17p13.3-17q25. The results from the FISH assay were then compared to the karyotypes prepared from the tumors. Ten of the 34 cases demonstrated an i(17q) by FISH and standard cytogenetics. Two PNETs were shown to have an i(17q) by FISH alone, and three additional tumors had deletions of 17p. Thus, a total of 15 of 34 (44%) of the PNETs in this series had a deletion of 17p. This study confirms and extends our previous reports that an i(17q) is the most common cytogenetic abnormality in PNETs. The interphase FISH assay which we employed will have clinical utility for diagnosis of children with malignant brain tumors, and it may be used for identification of tumors with 17p deletions for molecular studies aimed at identifying disease genes.

show abstract

“…Cytogenetic data on this tumor are still limited, in part, because of difficulties in obtainingadequate metaphase cells for chromosome banding analysis. T h e most common chromosomal aberration detected to date by chromosome banding is loss of 17p and gain of 17q, resulting from isochromosome i( 17q), which has been described in approximately 30% of cases (Bigner et al, 1988;Griffin et al, 1988;Biegel et al, 1989Biegel et al, , 1995Sawyer et al, 1991;Stratton et al, 1991;Karnes et al, 1992;Vagner-Capodano et al, 1992;Neumann et al, 1993;Fuji et al, 1994). Further recurrent aberrations include losses of chromosomal arms lp, 3q, 6q, l l p , l l q , 16q, Xp and chromosome 22 and gains of chromosomes 6 and 8.…”

Section: Introductionmentioning

confidence: 95%