A case of central perineurioma (Lazarus and Trombetta) of the mandible.

Kusama, Kaoru; Iwamoto, Akira; Mikuni, Masabumi; Komagamine, Masahiro; Suzuki, Takao; Yamamura, Junji; Kimura, Tomoe

doi:10.2334/josnusd1959.23.10

Cited by 41 publications

(14 citation statements)

References 10 publications

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“…Hornick and Fletcher separately reported ten cases in the intestinal tract (nine colonic and one jejunal) which presented as either polyps or submucosal mass lesions [3]. Perineuriomas have furthermore been reported in the stomach [4], kidney [5–7], lip [8], maxillary sinus [8] and mandible [9]. Giannini et al reported an intraventricular perineurioma [10].…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Perineurioma: An Unusual Soft Tissue Lesion in an Unreported Location

Duncan

Tharp

Branca

et al. 2010

Pathology Research International

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We report the first case of an endobronchial perineurioma, a rare benign neoplasm typically occurring in soft tissue. A 53-year-old nonsmoking female presented with a three-month history of persistent bronchitis. A CT scan followed by bronchoscopy demonstrated an endobronchial lesion involving the left mainstem bronchus. Removal of the lesion by bronchoscopy was accomplished. The tumor was composed of bland spindle cells in a variably collagenized stroma. These cells had long cytoplasmic processes. No mitotic activity or necrosis was observed. Neoplastic cells were immunoreactive for epithelial membrane antigen (EMA), CD34, and claudin-1. Smooth muscle actin (SMA), desmin, and S-100 immunostains were all negative. Based on the morphologic appearance and immunophenotype, a diagnosis of perineurioma was rendered.

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Section: Discussionmentioning

confidence: 99%

Endobronchial Perineurioma: An Unusual Soft Tissue Lesion in an Unreported Location

Duncan

Tharp

Branca

et al. 2010

Pathology Research International

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“…There are 3 reports of perineurioma Perineurioma occurring in the head and neck. Kusama et al [3] reported a perineurioma in the mandible of a 31-year-old female, while Tsang et al [10] and Mentzel et al [11] each report an example in the soft tissues of the neck.…”

Section: Discussionmentioning

confidence: 99%

“…Perineurioma is a rare tumor derived from perineurial cells. A review of the literature has revealed only 17 cases [1][2][3][4][5][6][7][8][9][10][11][12]. The term 'perineurioma' has, in the past, been incorrectly used to denote a predominantly reactive hy perplastic perineurial proliferation-localized hypertro phic neuropathy [10,[13][14][15][16][17][18][19], Some cases of localized hypertrophic neuropathy have been shown to represent a proliferation of perineurial cells, for which the term 'intraneural perineurioma' has been coined [20].…”

Section: Introductionmentioning

confidence: 99%

Perineurioma: An Unusual Cause of an External Auditory Canal Polyp

Donnellan

Rughubar

Govender

et al. 1997

ORL

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A 33-year-old woman presented with pruritus of the right ear and on examination was found to have 1 × 1 cm polypoid lesion in the external auditory canal. This was removed and histological examination revealed a well-circumscribed spindle cell lesion arranged in fascicles and whorls. Immunohistochemistry showed the tumor to be EMA-positive but S-100-, desmin-, actin-, and cytokeratin-negative. Ultrastructural examination confirmed perineurial cell origin. There are several lesions in which perineurial cells are present, but a true perineurioma is composed exclusively of perineurial cells. It has characteristic morphological, immunohistochemical and ultrastructural features that help separate it from other nerve and neuroectodermal lesions.

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“…Examples have been reported to occur in the mandible [16,17], gingiva [13,18], tongue [11], upper lip [11], lower lip [19], nasolabial fold [20] and retrotonsillar region [11]. Yet another mandibular case example was presented at the annual meeting of the Western Society of Teachers in Oral Pathology [21].…”

Section: Introductionmentioning

confidence: 97%

Intraoral Perineurioma, Soft Tissue Type: Report of Five Cases, Including 3 Intraosseous Examples, and Review of the Literature

Koutlas

Scheithauer

Folpe

2010

Head and Neck Pathol

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Soft tissue type perineuriomas (STP) are uncommon tumors, oral examples being very rare. They have been described in the mandible, gingiva, lips, retrotonsillar mucosa and maxillary vestibule. Herein, we report the clinicopathologic features of five STP, two affecting the buccal mucosa and three the mandible. Three patients were women and two men. All tumors were characterized by a proliferation of cytologically bland, mitotically inactive spindled cells with round, ovoid or spindled nuclei, embedded in a variably collagenous and myxoid matrix. Interestingly, two mandibular tumors featured psammoma bodies and one, in addition, contained irregular calcifications. Tumor cells showed the immunohistochemical profile of perineurial cells including epithelial membrane antigen, Glut-1, claudin-1 and collagen type IV. S100 and neurofilament proteins were not expressed by the tumor cells. A few minute, peripherally situated, entrapped nerves were identified. All tumors were reported gross-totally excised and no recurrences have taken place. The clinical characteristics of STP are summarized and its differential diagnosis relative to other spindle cells tumors and meningioma is discussed.

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A case of central perineurioma (Lazarus and Trombetta) of the mandible.

Cited by 41 publications

References 10 publications

Endobronchial Perineurioma: An Unusual Soft Tissue Lesion in an Unreported Location

Endobronchial Perineurioma: An Unusual Soft Tissue Lesion in an Unreported Location

Perineurioma: An Unusual Cause of an External Auditory Canal Polyp

Intraoral Perineurioma, Soft Tissue Type: Report of Five Cases, Including 3 Intraosseous Examples, and Review of the Literature

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