A case of catatonia resembling frontotemporal dementia and resolved with electroconvulsive therapy

Suzuki, Kazumasa; Takano, T.; Matsuoka, Hiroo

doi:10.1080/15622970701701021

Cited by 17 publications

(11 citation statements)

References 4 publications

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“…Repeated studies have shown the efficacy of ECT on unipolar as well as bipolar depression [7, 8]. ECT has also been shown effective in a case of catatonia resembling FTD [9]. The confirmation of FTD based on post-ECT MRI further strongly discredits a potential role for catatonia in this patient.…”

Section: Discussionmentioning

confidence: 93%

Efficacy of Electroconvulsive Therapy for Comorbid Frontotemporal Dementia with Bipolar Disorder

Paul

Goetz²,

Bennett³

et al. 2013

Case Reports in Psychiatry

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Challenges encountered in the diagnosis and treatment of frontotemporal dementia (FTD) are further confounded when presented with comorbid psychiatric disorder. Here we report a case of progressive FTD in a patient with a long history of bipolar affective disorder (BAD) 1, depressed type. We also report beneficial effects of electroconvulsive therapy and its potential application in similar comorbid disorders.

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Section: Discussionmentioning

confidence: 93%

Efficacy of Electroconvulsive Therapy for Comorbid Frontotemporal Dementia with Bipolar Disorder

Paul

Goetz²,

Bennett³

et al. 2013

Case Reports in Psychiatry

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“…Additionally, the association between bvFTD and FTLD‐TDP type C has not been shown, so this case would be atypical in that regard. Several cases of clinical FTD with catatonic syndrome have been reported . but these were not pathologically examined.…”

Section: Discussionmentioning

confidence: 99%

Frontotemporal dementia with trans‐activation response DNA‐binding protein 43 presenting with catatonic syndrome

et al. 2017

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Catatonia is a clinical syndrome characterized by symptoms such as immobility, mutism, stupor, stereotypy, echophenomena, catalepsy, automatic obedience, posturing, negativism, gegenhalten and ambitendency. This syndrome occurs mostly in mood disorder and schizophrenic patients, and is related to neuronal dysfunction involving the frontal lobe. Some cases of frontotemporal dementia (FTD) with catatonia have been reported, but these cases were not examined by autopsy. Here, we report on a FTD case which showed catatonia after the first episode of brief psychotic disorder. At the age of 58, the patient had a sudden onset of disorganized behavior and meaningless speech. Psychotropic drugs were effective for catatonic symptoms. However, after remission apathy, hyperorality, socially inappropriate behavior, hoarding, and an instinctive grasp reaction appeared and persisted. Brain MRI showed significant atrophy of the bilateral fronto-temporal lobes. A neuropathological examination revealed extensive trans-activation response DNA-binding protein 43 (TDP-43) positive neurocytoplasmic inclusions and dystrophic neurites in the brain, including the cerebral cortex, basal ganglia, and brainstem. Pathological diagnosis was frontotemporal lobar degeneration (FTLD) with TDP-43 (FTLD-TDP) type C, which was also confirmed by the band pattern of C-terminal fragments of TDP-43 on western blotting of sarkosyl-insoluble fractions extracted from the frozen brain. Dysfunction of the thalamus, globus pallidus, supplementary motor area, amygdala and cingulate cortex have been said to be related to the catatonic syndrome. In this case, these areas were affected, showing abnormal TDP-43-positive structures. Further studies are expected to confirm further clinical - pathological correlations to FTLD.

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“…There have been a few reports concerning the relationship between FTD and catatonia . Northoff et al .…”

Section: Discussionmentioning

confidence: 99%

“…7 There have been a few reports concerning the relationship between FTD and catatonia. [7][8][9] Northoff et al pointed out that it is not surprising to observe catatonic symptoms in FTD because catatonia is linked to frontal dysfunction. 10 The present patients did not fill all the diagnostic criteria for FTD.…”

Section: Discussionmentioning

confidence: 99%

Three patients with mood disorders showing catatonia and frontotemporal lobes atrophy

2013

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Here we report the cases of three patients with mood disorders showing catatonia and frontotemporal lobe atrophy. Catatonia is a syndrome linked to frontal dysfunction that most frequently occurs in patients with mood disorders. The diagnostic criteria of catatonia and frontotemporal dementia partly overlap. In the present patients, catatonia might be closely related to frontal dysfunction caused by frontotemporal lobe atrophy. With regard to therapeutics for catatonia, we found that administering a low dose of lorazepam alone or after electroconvulsive therapy may be useful for treating and preventing catatonia. We also found that administering glutaminate antagonists such as memantine may be useful for treating lorazepam-resistant catatonia.

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A case of catatonia resembling frontotemporal dementia and resolved with electroconvulsive therapy

Cited by 17 publications

References 4 publications

Efficacy of Electroconvulsive Therapy for Comorbid Frontotemporal Dementia with Bipolar Disorder

Efficacy of Electroconvulsive Therapy for Comorbid Frontotemporal Dementia with Bipolar Disorder

Frontotemporal dementia with trans‐activation response DNA‐binding protein 43 presenting with catatonic syndrome

Three patients with mood disorders showing catatonia and frontotemporal lobes atrophy

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