A case of Candida krusei peritonitis secondary to duodenal perforation due to Candida duodenitis

Abstract

A case of a 62-year-old man with Candida krusei peritonitis secondary to duodenal perforation due to Candida duodenitis that was successfully treated with a 14-day course of caspofungin is reported. The potential role of Candida infection in the pathogenesis of peptic ulcers and duodenal perforation is considered. If this role is confirmed, antifungal treatment should be included in the therapeutic armamentarium of peptic disease.

Unusual Presentation and Complications of New-Onset Type 1 Diabetes in a 3-Year-Old

“…7 Candida peritonitis associated with perforated duodenal ulcers has also been reported in adults. 8,9 We present the second reported case of small bowel perforation associated with Candida infection in a pediatric DKA patient and the first case in an initial presentation of T1DM. The first reported case was in a 17-year-old boy with known T1DM who developed diffuse abdominal pain after resolution of acidosis and was found to have necrosis of the terminal ileum with acute inflammatory reaction and a small number of Candida species noted on the serosal and mucosal surfaces.…”

“…7 Candida peritonitis associated with perforated duodenal ulcers has also been reported in adults. 8,9…”

First reported case series of Candida krusei peritonitis secondary to a perforated viscus

“…Similar to our case series, Cascio et al reported a case of Candida krusei peritonitis secondary to a duodenal perforation initially treated with fluconazole and replaced with caspofungin. 16,17 This led to resolution of the patient's septic shock within 48 hours. As such, Candida krusei, as a causal pathogen for abdominal sepsis should be considered in all patients not responding to standard antifungal therapy.…”

Fungal Peptic Ulcer Disease in an Immunocompetent Patient

“…It is important for clinicians to maintain a higher index of suspicion for other causes of PUD for correct and prompt management. Cascio et al, 2011 [7] Nishimura et al, 2011 [8] 73, F Unknown (article in Japanese) None Two gastric ulcers with thick exudates in the fornix…”