A case of black urine and dark skin — cresol poisoning

Seak, Chen-Ken; Lin, Chih-Chuan; Seak, Chen-June; Hsu, Tai-Yi; Chang, Chi-Chung

doi:10.3109/15563650.2010.523830

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…Ceux-ci ne sont toutefois pas disponibles en pratique courante et, bien que la littérature internationale compte un certain nombre de cas rapportés d'intoxication aux crésols, peu d'entre eux comportent les dosages sériques ou urinaires. Seak décrit en 2010 la prise en charge complète d'un patient 3 h après une tentative de suicide par ingestion d'une quantité incertaine de crésol à 50 % pour laquelle les dosages et, plus tard, la présentation du flacon n'ont fait que confirmer la suspicion clinique qui est donc, en pratique, essentiellement tributaire du contexte de la découverte 13 .…”

Section: Discussionunclassified

About a cresol intoxication

Fatihi¹,

Mols²

2018

Rev Med Brux

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Cresols are phenol derivatives commonly used as surface disinfectants. Ingestion may cause local mucocutaneous damage and extensive systemic toxicity : central nervous, cardiovascular, hematological, hepatic, renal and pulmonary. We describe the case of a 33-year-old woman who swallowed, without suicidal intent, 50 to 70 cm3 of a 50% cresol solution. Coma occurred within 5 minutes of ingestion, she presented a bradypnea with desaturation, and the SMUR team performed on-site an orotracheal intubation. On arrival at the hospital, the patient had typical caustic lesions around her mouth. Immediate management consisted of ventilatory support, instillation of activated charcoal by nasogastric tube, empirical intravenous methylene blue and effective vascular filling. Within one hour of admission, she developed hypotension, ventricular arrhythmias, and acute renal failure. Toxic hepatitis occurred within 24 hours. The 24-hour gastroscopy showed erosive esophagitis and erythematous gastropathy and duodenopathy. No urine or blood dosage can be performed. The patient left the hospital on the fifth day and her liver function normalized after one month. The treatment of phenol poisoning consists primarily of rapid decontamination and the support of vital functions. Diagnostic assays are not available routinely and anamnesis, as well as some semiological cardinal points, is essential.

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Section: Discussionunclassified

About a cresol intoxication

Fatihi¹,

Mols²

2018

Rev Med Brux

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“…There are few case reports among adults mentioning skin exposure with phenols leading to systemic side effects. [3456] Pediatric case reports are fewer with hardly any mention of correlation if any between percentage of skin exposure and degree of systemic side effects. [2] In children, as the ingestion is usually accidental, majority of the exposure is likely secondary to spitting or spilling over various body parts.…”

Section: Discussionmentioning

confidence: 99%

“…Various mechanisms have been proposed for phenol-induced AKI ranging from excretion of unconjugated phenol damaging the glomeruli and renal tubules, renal ischemia, formation of casts due to hemoglobin precipitation, and depleted glutathione levels. [34]…”

Section: Discussionmentioning

confidence: 99%

Acute carbolic acid poisoning: A report of four cases

Giri

Sinha

Sikka

et al. 2016

Indian Journal of Critical Care Medicine

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Phenol (carbolic acid) is one of the oldest antiseptic agents. Apart from being used in many commercially available products, in rural India, it is often used in the household to prevent snake infestation. We hereby present four cases of acute carbolic acid poisoning which we saw over the last monsoon. The cases highlight the multiple routes of absorption of carbolic acid as well as its multi-organ complications which often necessitate intensive care of local therapy decreases systemic phenol absorption from cutaneous exposure and may help in reducing severity.

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“…Broadly, these include: a) drugs [1,2] b) endogenous substances such as urobilinogen [3], and c) pathologic conditions such as hemolysis [4,5] and alkaptonuria [6]. Intoxication from a widely used disinfectant, cresol has also been reported to cause black urine [7][8][9].…”

Section: Introductionmentioning

confidence: 99%