A case of bilateral Parry‐Romberg syndrome successfully treated with hyaluronic acid filler augmentation

Abstract

Parry-Romberg syndrome is a rare acquired neurocutaneous disorder typically characterized by hemifacial atrophy. Few cases of bilateral facial involvement have been reported. We report a case of a 60-year-old female with a 20-year history of progressive bilateral facial atrophy. Although an initial diagnosis of acquired partial lipodystrophy was considered, a diagnosis of bilateral Parry-Romberg was favored for three main reasons: (a) lipoatrophy was confined to the face (b) imaging findings of enophthalmos and underlying white matter changes (c) laboratories showing absence of C3 nephritic factor and normal complement levels. The patient was treated with hyaluronic acid fillers with dramatic improvement in cosmetic appearance. K E Y W O R D S hyaluronic acid filler, lipoatrophy, Parry-Romberg How to cite this article: Watchmaker J, Saadeh D, Lam C, Vashi NA. A case of bilateral Parry-Romberg syndrome successfully treated with hyaluronic acid filler augmentation. J Cosmet

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Progressive facial hemiatrophy (Parry-Romberg syndrome): short case report

“…It also has been shown that conversion of localized scleroderma to PRS has been reported, and that 30-40% patients with PRS present with typical scleroderma changes [4]. Lipoatrophy (also described as Barraquer-Simons syndrome) has also to be eliminated: the lipoatrophy is systemic and not limited to the face, and there are complement levels abnormalities and C3 seric nephritic factor [14,15]. Nonetheless, these 2 diseases are also strongly associated [16].…”

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