A Case of Bazex Syndrome With Genital Involvement

Graves, Michael S.; Hardin, Mary E.; Davis, Loretta S.

doi:10.1001/jamadermatol.2014.2110

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Our patient demonstrated onychomadesis of finger nails like the patient of Graves et al [7]. Other nail findings are subungual keratosis, yellowish discoloration, ridging, and onycholysis [2].…”

Section: Discussionsupporting

confidence: 65%

“…There is a male predominance. Tumors of upper airways and digestive tract are on top of malignancies associated with Bazex-syndrome [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…Typically, these lesions occur symmetrical on acral body parts like ears, nose, hands and feet [2][3][4][5]. Uncommon manifestations include flexural Bazex-syndrome, which was seen in a patient with tonsillar adenocarcinoma [6], or genital involvement [7]. Histopathology of cutaneous lesions is non-specific psoriasiform.…”

Section: Discussionmentioning

confidence: 99%

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Bazex-syndrome with esophageal cancer

Boldt¹,

Wollina²

2016

Our Dermatol Online

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Section: Discussionsupporting

confidence: 65%

“…There is a male predominance. Tumors of upper airways and digestive tract are on top of malignancies associated with Bazex-syndrome [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

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Bazex-syndrome with esophageal cancer

Boldt¹,

Wollina²

2016

Our Dermatol Online

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“…Reported topical ointments include topical corticosteroids, as clobetasol 0.05% or betamethasone 0.01%, salicylic acid 10% in vaseline, itraconazole, isosorbide dinitrate, fluconazole, cephalexin, keratolytics, neomycin, nystatin, zinc ointment, antibiotic and emollients. The recommended starting dose for oral steroids is prednisolone 0.5 mg/kg/day, slowly tapering over a month or initiating with 60 mg/day .…”

Section: Resultsmentioning

confidence: 99%

Acrokeratosis paraneoplastica (Bazex syndrome) – a systematic review on risk factors, diagnosis, prognosis and management

Räßler

Goetze

Elsner

2017

Acad Dermatol Venereol

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Acrokeratosis paraneoplastica Bazex (Bazex syndrome) is a rare paraneoplastic skin disease defined by erythematous, violaceous, scaly plaques on the hands and feet and on other acral locations such as nose and ears. Bazex syndrome is linked to a variety of underlying malignancies. Usually the skin lesions develop prior to the diagnosis of an internal malignant neoplasm with spontaneous remission after tumour removal. The objective of this study was to review the so far reported risk factors, diagnostic work-up, prognosis and treatment options for Bazex syndrome in a systematic manner. This systematic review is based on a search in MEDLINE, EMBASE and Cochrane Central Register for English and German articles from 1990 to 2015. Evidence on the diagnosis and treatment of Bazex syndrome is limited predominately to case reports or to small case series. There are no randomized controlled trials. A number of underlying tumour entities, predominately oropharyngeal neoplasms and tumours of the gastroenterological tract, but other malignancies were reported. Treatment modalities including topical and systemic corticosteroids, salicylic acid, topical vitamin D analogues, etretinate and PUVA therapy are often ineffective. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic review was to call attention to this rare condition and to help clinicians to diagnose and treat Bazex syndrome effectively. Because of the good prognosis of the skin lesions and the tendency to resolve spontaneously if the underlying tumour is treated early, the differential diagnosis of Bazex syndrome should be taken into consideration when dealing with atypical psoriasiform cutaneous lesions. An early diagnosis may improve the patient's prognosis substantially.

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Dermatologic Manifestations of Internal Malignancies and Paraneoplastic Syndromes

Sanches

Miyashiro

2023

Oncodermatology

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A Case of Bazex Syndrome With Genital Involvement

Cited by 9 publications

References 6 publications

Bazex-syndrome with esophageal cancer

Bazex-syndrome with esophageal cancer

Acrokeratosis paraneoplastica (Bazex syndrome) – a systematic review on risk factors, diagnosis, prognosis and management

Dermatologic Manifestations of Internal Malignancies and Paraneoplastic Syndromes

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