2021
DOI: 10.1016/j.jdcr.2020.12.013
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A case of B-cell lymphoblastic leukemia cutis flaring following CAR T-cell therapy in a patient with refractory acute lymphoblastic leukemia

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(3 citation statements)
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“…4,5 This report adds to this knowledge by demonstrating serial histopathology consistent with CAR-T cells at work within leukemic infiltrates. 4,5 Additionally, our case highlights that hemophagocytosis could also be an attribute of effector function of CAR-T, a known extreme variant of CRS, carHLH. 6,7 Indeed, the flare of LC and the noted T-cell infiltrate with cellular debris and phagocytosis following CAR-T infusion likely indicate a favorable response, but data are limited to allow definitive conclusions about the long term prognostic and predictive value of this finding.…”
Section: Discussionmentioning
confidence: 55%
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“…4,5 This report adds to this knowledge by demonstrating serial histopathology consistent with CAR-T cells at work within leukemic infiltrates. 4,5 Additionally, our case highlights that hemophagocytosis could also be an attribute of effector function of CAR-T, a known extreme variant of CRS, carHLH. 6,7 Indeed, the flare of LC and the noted T-cell infiltrate with cellular debris and phagocytosis following CAR-T infusion likely indicate a favorable response, but data are limited to allow definitive conclusions about the long term prognostic and predictive value of this finding.…”
Section: Discussionmentioning
confidence: 55%
“…Case reports have also demonstrated flaring of LC in response to CAR‐T and that disease flare may not necessarily be indicative of CAR‐T therapy failure 4,5 . This report adds to this knowledge by demonstrating serial histopathology consistent with CAR‐T cells at work within leukemic infiltrates 4,5 . Additionally, our case highlights that hemophagocytosis could also be an attribute of effector function of CAR‐T, a known extreme variant of CRS, carHLH 6,7 .…”
Section: Discussionmentioning
confidence: 56%
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