A Case of Autoimmune Progesterone Dermatitis Misdiagnosed as Allergic Contact Dermatitis

Lee, Myoung Kyu; Lee, Won Yeon; Yong, Suk Joong; Shin, Kye Chul; Lee, Shun Nyung; Lee, Ji Ho; Kim, Sang-Ha

doi:10.4168/aair.2011.3.2.141

Cited by 29 publications

(22 citation statements)

References 14 publications

(21 reference statements)

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“…Progesterone hypersensitivity is a rare entity with variable presentation varying from dermatitis,[ 5 6 ] dyspnea, cough, and anaphylaxis. [ 7 ] The first case was reported by Shelley et al .…”

Section: Discussionmentioning

confidence: 99%

Progesterone hypersensitivity: A challenge for luteal support

Gupta

Goenka

2018

J Hum Reprod Sci

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Progesterone hypersensitivity is a rare phenomenon which can occur after both endogenous and exogenous exposures. We present a case of hypersensitivity to various forms and routes of exogenous progesterone. A 27-year-old female presented with primary infertility. Investigations revealed Grade 1 endometriosis and polycystic ovary syndrome. Three cycles of intrauterine insemination were attempted which were unsuccessful and in vitro fertilization was proceeded. Six blastocysts of Grade A were formed and cryopreserved. Artificial cycle was used for endometrial preparation for frozen embryo transfer (FET). However, due to failure to use exogenous progesterone due to hypersensitivity reaction, Modified Natural Cycle (MNC) was used. A follicle was formed using ovulation induction with tamoxifen and human menopausal gonadotropin. Ovulation was induced by human chorionic gonadotropin (hCG), and natural progesterone from corpus luteum was used. FET was done when endometrium was 8 mm. Pregnancy was confirmed by transvaginal ultrasound and β-hCG levels and continued uneventfully. Endogenous progesterone can be used as an alternative for endometrial preparation for FET in patients with exogenous progesterone hypersensitivity.

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Section: Discussionmentioning

confidence: 99%

Progesterone hypersensitivity: A challenge for luteal support

Gupta

Goenka

2018

J Hum Reprod Sci

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“…Kilo alma, hipertrikoz, ses kalınlaşması, baş ağrısı, libido değişiklikleri, hepatosellüler hasar gibi yan etkiler kullanımını kısıtlar. GnRH analogları gibi danazol da dirençli olgularda kullanılması gereken bir tedavi seçeneğidir (9). Bir numaralı olgu 2 aydır GnRH analogu tedavisi almaktadır.…”

Section: Discussionunclassified

Autoimmune Progesterone Dermatitis: Two Case Reports

Benar¹,

Cemil²,

Atay³

et al. 2018

tdd

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Otoimmün progesteron dermatiti, nadir görülen ve endojen progesterona karşı gelişen bir hipersensitivite reaksiyonudur. Döngüsel olarak menstrüel siklusun luteal fazında başlayıp, menstrüel kanamanın başlamasından sonra sonlanan, kutanöz ve mukokutanöz bulgularla karakterize bir durumdur. Bu çalışmada, ürtikeryal lezyonlarla seyreden ve otoimmün progesteron dermatiti tanısı konulan 42 ve 49 yaşındaki iki olgu sunulmaktadır. Her iki hastanın da menstrüel kanamadan bir ya da iki hafta önce başlayıp, kanamayla birlikte sonlanan ürtikeryal döküntü öyküsü vardı. Parenteral progesteron preparatı ile yapılan intradermal testler her iki hastada da pozitif olarak saptandı. Hastaların öyküsü, klinik bulguları ve progesteron ile yapılan intradermal testin pozitif olması sonucunda otoimmün progesteron dermatiti tanısı kondu. Bu çalışma, nadir görülen bir hastalık olması nedeniyle tanının atlanabileceğini ve iyi bir anamnezin tanıdaki önemini vurgulamak amacıyla sunulmuştur. Öz AbstractAutoimmune progesterone dermatitis is a rare hypersensitivity reaction that develops against endogenous progesterone. This condition is characterized by cutaneous and mucocutaneous findings that begins cyclically in the luteal phase of the menstrual cycle and ends after the onset of menstrual bleeding. In this study, we present two cases aged 42 and 49 years who were had urticarial lesions and diagnosed with autoimmune progesterone dermatitis. Both patients had a history of urticaria rash that started one or two weeks before the menstruation and ended with bleeding. Intradermal tests with parenteral progesterone preparation were found to be positive in both patients. As a result of patients' history, clinical findings and the positive intradermal test with progesterone, autoimmune progesterone dermatitis diagnosed. It has been aim to emphasize the importance of anamnesis in diagnosis of this rarely seen disease.

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“…Untreated symptoms have not been reported to spontaneously remit, other than during pregnancy as described above or at menopause. 48 Because there have been no longitudinal prospective studies on patients with PH, the natural history is poorly understood. Symptomatic treatment with antihistamines or topical corticosteroids may be helpful.…”

Section: Prognosismentioning

confidence: 99%

Presentation and natural history of progestogen hypersensitivity

Foer

Buchheit

2019

Annals of Allergy, Asthma & Immunology

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Progestogen hypersensitivity is a heterogeneous syndrome with multiple clinical manifestations, including dermatitis, urticaria, asthma, and anaphylaxis. Progestogen hypersensitivity symptoms can be triggered by ovarian or placental endogenous progesterone or exogenous progestins used for contraception or fertility treatments. The underlying pathogenesis of progestogen hypersensitivity is poorly understood but is likely multifactorial given the variety of triggers and clinical manifestations seen in progestogen hypersensitivity. Medical management and desensitization are the mainstays of treatment for progestogen hypersensitivity particularly for patients interested in fertility and conception.

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A Case of Autoimmune Progesterone Dermatitis Misdiagnosed as Allergic Contact Dermatitis

Cited by 29 publications

References 14 publications

Progesterone hypersensitivity: A challenge for luteal support

Progesterone hypersensitivity: A challenge for luteal support

Autoimmune Progesterone Dermatitis: Two Case Reports

Presentation and natural history of progestogen hypersensitivity

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