A case of associated thyrotoxicosis and phaeochromocytoma. A diagnostic problem

Abstract

A case of phaeochromocytoma and thyrotoxicosis occurring in the same patient is described, in which the similarity between the signs and symptoms produced by the two conditions delayed full diagnosis until post mortem. The mechanisms involved in the production of these signs and symptoms are discussed.

Relapse of Graves' Disease in a Patient with Pheochromocytoma

“…While such comorbidity is rare [3][4][5][6], a similar case has been reported by Paschke et al, in whom Graves' disease that had been in remission for 5 years suffered a relapse following development of pheochromocytoma [6]. The relapse of Graves' disease occurs at any time in life, but the majority does so within the first two years after discontinuation of antithyroid treatment [7,8].…”

“…Association of Graves' disease with other autoimmune disorders, such as Sjögren's syndrome and myasthenia gravis has been frequently reported [2]. However, the concomitance of Graves' disease and pheochromocytoma is rare [3][4][5][6].…”

Pheochromocytoma/Ganglioneuroma and Auto-Immunity: Report of Two Cases

“…Bartolomei,et al [17] have pointed out a case with pheochromocytoma accompanying autoimmune hypothyroidism. Pheochromocytoma was shown to accompany not only hypothyroidism but also hyperthyroidism and goiter [18][19][20]. Thyroid gland swelling with a subsequent diagnosis of pheochromocytoma was first reported in 1947 [21], followed by other studies.…”

Graves′ disease allied with multiple pheochromocytoma

“…The association of pheochromocytoma and Graves’ disease is exceptional. [4] It raises a three-fold problem of diagnosis, treatment, and prognosis. On the diagnostic level, the overlapping of symptoms involved for the most part in the two pathologies of hypercathecholaminemia can mislead the diagnosis of one or another of the two pathologies, while the outcome of one or the other may be fatal during any invasive procedure.…”