A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy

Savoia, Francesco; Gaddoni, Giuseppe; Casadio, Chiara; Patrizi, Annalisa; Spadola, Giuseppe; Bassi, Paolo; Albertini, Francesco; Ballardini, G.; Briganti, Elisabetta; Casolari, Stefania; Donà, Davide De; Menni, B; Zanotti, Miriam; Angelis, Paolo De

doi:10.5070/d33kc8k73q

Cited by 10 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…cases were male. The primary diagnoses associated with these cases were rheumatoid arthritis [ 1 , 16 ], molar pregnancies [ 2 , 17 ], psoriatic arthritis [ 13 , 18 ], cutaneous psoriasis [ 19 ], and T-cell lymphoma [ 20 ]. The diagnosis of pericardial effusion was typically made using clinical and imaging techniques, such as echocardiography, chest X-ray, computerized thoracic tomography, and electrocardiography.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that, while these cases suggest an association between the use of MTX and pericardial or pleural effusion, further research is needed to establish a causal relationship. Close monitoring of patients using MTX for potential adverse events such as pericardial effusion is crucial, and any symptoms should be reported to their healthcare provider [1,13,[16][17][18][19][20].…”

Section: Table 2: Summary Of Reviewed Casesmentioning

confidence: 99%

See 1 more Smart Citation

Pericarditis Induced by Methotrexate: A Case Report and Literature Review

Guevara¹,

Hernandez²,

Rosado³

et al. 2023

Cureus

View full text Add to dashboard Cite

Methotrexate (MTX) is a crucial part of the management of rheumatoid arthritis (RA). Although MTX is generally well tolerated, it is not exempt from adverse effects. The side effects of MTX are diverse, and pericarditis, as demonstrated in our case, is one of the rarest adverse effects. Therefore, it is crucial to rule out common causes of pericarditis, such as infections, malignancies, or other underlying conditions. However, once common causes are excluded, MTX-induced pericarditis should always be considered, and MTX should be discontinued without resumption due to potential relapse. Furthermore, the timing of MTX initiation is not significant; patients may have been on chronic MTX treatment or have recently started it. Moreover, pericarditis secondary to MTX is not exclusive to patients with rheumatological conditions but can also occur in other conditions.

show abstract