A Case of Aplastic Anaemia in Pregnancy

Bigby, Mary A. M.; Jones, F. Avery

doi:10.1111/j.1471-0528.1946.tb03899.x

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…Of 17 reported cases of pregnancyassociated SAA that we reviewed, only one other reported patient was a teenager. [3][4][5][6][7][8][9][10][12][13][14][15][16][17][18][19][20][21] In that case, a 19-year-old primigravida female was diagnosed at 14 weeks of GA. At 20 weeks of GA she was started on cyclosporine and GM-CSF. She underwent spontaneous labor at 31 weeks of GA.…”

Section: Discussionmentioning

confidence: 98%

“…These include infectious, metabolic, and nutritional causes, some of which may be reversible with appropriate intervention. 12 There have been sporadic reports of aplastic anemia occurring during pregnancy and these have been characterized by high mortality rates of 20% to 60% for the mother. [3][4][5][6][7][8][9][10] A condition of severe pancytopenia with marrow depression associated with pregnancy secondary to either an inhibitor or absence of a stimulatory signal was described in 1968.…”

Section: Discussionmentioning

confidence: 99%

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Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Abdel‐Azim

Jovi-Usude

Balian

et al. 2015

Journal of Pediatric Hematology/Oncology

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Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Abdel‐Azim

Jovi-Usude

Balian

et al. 2015

Journal of Pediatric Hematology/Oncology

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Prognostic aspects of aplastic anemia in pregnancy

Suda

Omine

Tsuchiya

et al. 1978

Blut

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Our resent experience on six cases of aplastic anemia complicated with pregnancy is described. In addition, 43 similar cases were collected from the literature and reviewed to analyze some prognostic aspects of this relatively rare but potentially serious complication. Clinical and hematological data were treated to extract some clinically meaningful factors in relation to the success and failure of pregnancy. Among initial hematological parameters, no significant difference was found between successful and unsuccessful cases with an exception of hemoglobin concentration. The patients diagnosed as aplastic anemia prior to conception demonstrated an better outcome of pregnancy as well as survival rate of mother when compared with those diagnosed during pregnancy. Mortality has apparently improved after the late 1950's. Success rate of pregnancy before 1958 was 21%, while it was 67% and 71% in the era of 1959-1969 and after 1970, respectively. However, hemorrhage and infection remained to be two major causes of maternal death in both eras. Based on these observations, the currently recommendable attitude to this complication is discussed.

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Refractory anemias of pregnancy

Holly¹

1960

American Journal of Obstetrics and Gynecology

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A Case of Aplastic Anaemia in Pregnancy

Cited by 9 publications

References 2 publications

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Prognostic aspects of aplastic anemia in pregnancy

Refractory anemias of pregnancy

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