A Case of Angiosarcoma of the Breast

Ohta, Masatoshi; Tokuda, Yutaka; Kuge, Soichi; Okumura, Akihisa; Tanaka, Maki; Kubota, Mitsuhiro; Tajima, Tomoo; Akatsuka, Akira; Osamura, R Y; Tamaoki, Norikazu; Mitomi, Toshio

doi:10.1093/jjco/27.2.91

Cited by 33 publications

(34 citation statements)

References 25 publications

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“…The most common site of distant metastases reported by Søndenaa et al was the liver 12 , and in our group the most common site of metastasis was lungs. Primary angiosarcoma diagnosis is confirmed by core biopsy 13 as fine-needle biopsy leads to approximately 40% of false negative results 14 . Other rare histologies, such as liposarcoma, fibrosarcoma, osteosarcoma, metaplastic carcinoma, and stromal sarcoma, are excluded as part of a differential diagnosis 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Primary angiosarcoma diagnosis is confirmed by core biopsy 13 as fine-needle biopsy leads to approximately 40% of false negative results 14 . Other rare histologies, such as liposarcoma, fibrosarcoma, osteosarcoma, metaplastic carcinoma, and stromal sarcoma, are excluded as part of a differential diagnosis 13 . Presence of CD31 and factor viii in immunohistochemical assessment are diagnostic features of pas in the pathological report, related to the vascular origin of the tumour 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Other rare histologies, such as liposarcoma, fibrosarcoma, osteosarcoma, metaplastic carcinoma, and stromal sarcoma, are excluded as part of a differential diagnosis 13 . Presence of CD31 and factor viii in immunohistochemical assessment are diagnostic features of pas in the pathological report, related to the vascular origin of the tumour 13 . About one third of angiosarcomas were discovered during routine mammography 15 .…”

Section: Discussionmentioning

confidence: 99%

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Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

et al. 2018

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Angiosarcomas of the breast are rare parenchymal malignancies of the chest wall. Surgery is the main treatment modality with chemotherapy and radiotherapy used in case of recurrence. With generally unfavourable prognosis and lack of clear treatment guidelines due to its rarity and scarcity of available data, angiosarcoma of the breast is a challenging clinical situation for both oncologist and patient. We present here the results of a series of 11 consecutive primary angiosarcoma cases treated at our institute between 2000 and 2015.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

et al. 2018

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“…Primary breast angiosarcoma is more frequent in young women (20 to 50 years) with no previous cancer history or other known risk factors [1,2]. Between 6 and 12 % of primary breast angiosarcomas are diagnosed during pregnancy or shortly after, suggesting hormonal involvement.…”

Section: Discussionmentioning

confidence: 99%

“…However in present case the diagnosis could be made pre-operatively on NCB with help of IHC. Differential diagnosis of this rare tumor include: benign hemangioma, cystosarcoma phyllodes, stromal sarcoma, metaplastic carcinoma, fibrosarcoma, liposarcoma, squamous cell carcinoma with sarcomatoid features, myoepithelioma, fibromatosis, and reactive spindle cell proliferative lesion [2,8]. Surgical resection with mastectomy is the usual treatment.…”

Section: Discussionmentioning

confidence: 99%

Primary Angiosarcoma of Breast: A Case Report

Raju

Mahajan

Rehmani

et al. 2014

Indian J Surg Oncol

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Primary breast sarcomas are rare entities. These malignant tumors originate from mesenchymal glandular breast tissue and account for <1 % of all breast cancer cases. Angiosarcomas are rare malignant tumors that arise from endothelial cells lining vascular channels. Most angiosarcomas are secondary to radiotherapy treatments for breast cancer or to an arm lymphoedema subsequent to a modified radical mastectomy. Primary angiosarcomas are rare and account for 0.04 % of all malignant breast tumors. Keywords Breast . Primary angiosarcoma Case reportA 22 year old female presented with 4 months history of awareness of painless progressive lump in left breast. There was no history of previous breast surgery or irradiation. On examination there was a large lump occupying all quadrants of left breast with skin nodules and plaques and pinkish blue discoloration (Fig. 1a). Examination of axilla was unremarkable. Trucut biopsy from the lump was suggestive of vascular channels dissecting the stroma. Vascular channels were lined by plump endothelial cells with extensive haemorrhage and focal mitotic activity. Morphology suggested possibility of angiosarcoma. Immunohistochemistry (IHC) was positive for CD 31 and CD 34. Based on these findings provisional diagnosis of angiosarcoma of left breast was kept. Chest radiograph, ultrasonography of abdomen and F-18 bone scan were negative for metastatic disease. Patient underwent total mastectomy with level I axillary lymph node dissection with latissimus dorsi myocutaneous flap reconsruction. On gross examination tumour was well circumscribed measuring 17× 14×7 cm. Histopathologic examination (HPE) showed large gaping vascular channels lined by endothelial cells, focally arranged as lobular aggregates with atypical mitosis (5-6 per 10 high power fields) and focally congested vascular channels (Fig. 1b). All margins were free of tumour. All 7 nodes resected were negative for malignancy. IHC was negative for cytokeratin and positive for CD 31 (Fig.1c) and CD 34. IHC was negative for estrogen and progesterone receptors. More than 75 % of bulk of tumour was formed by well differentiated pattern but there were significant foci showing solid areas with marked pleomorphism and mitotic activity. So, diagnosis of primary intermediate grade angiosarcoma of breast was made. Patient received 50 Gy radiation therapy to chest wall (2 Gy per fraction over 5 weeks) followed by three cycles of adriamycin and ifosfamide based chemotherapy. Following third cycle of chemotherapy she complained of bone pains. F-18 bone scan was done and it was suggestive of multiple bone metastasis while contrast enhanced computed tomogram of chest, abdomen and pelvis was negative for metastasis. DiscussionPrimary breast angiosarcoma is more frequent in young women (20 to 50 years) with no previous cancer history or other known risk factors [1,2]. Between 6 and 12 % of primary breast angiosarcomas are diagnosed during pregnancy or shortly after, suggesting hormonal involvement. However, cases reported to display ...

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Intravascular papillary endothelial hyperplasia (Masson’s tumour) of the lower eyelid—a rare tumour of the orbital region

Rajagopal¹

2020

Eur J Plast Surg

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A Case of Angiosarcoma of the Breast

Cited by 33 publications

References 25 publications

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

Primary Angiosarcoma of Breast: A Case Report

Intravascular papillary endothelial hyperplasia (Masson’s tumour) of the lower eyelid—a rare tumour of the orbital region

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