A case of angioimmunoblastic lymphadenopathy with dysproteinemia(AILD) associated with nephrotic syndrome which remitted after double filtration plasma pheresis(DEPP) therapy.

Angioimmunoblastic T-cell lymphoma and membranous nephropathy: a still unreported association

“…In a retrospective study of renal manifestations in 700 patients with non-Hodgkin's lymphomas and chronic lymphocytic leukemia, only five biopsy-proven cases with glomerular diseases were found: one patient with chronic lymphocytic leukemia developed nephrotic syndrome due to MN [26]. A review of the literature demonstrated that a wide spectrum of renal lesions in the glomeruli, tubulointerstitium, and vessels can develop in patients with AITL [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. To our knowledge, there are only four reported cases of AITL and nephrotic syndrome: histological diagnosis was minimal-change disease [9,10], proliferative glomerulonephritis [11], or amyloid A-type amyloidosis [12].…”

“…These include proteinuria (focal proliferative glomerulonephritis) [8], nephrotic syndrome (minimal-change disease [9,10], proliferative glomerulonephritis [11], and amyloid A-type amyloidosis [12]), acute renal failure (various proliferative glomerulonephritis [13][14][15], immunoglobulin M (IgM)-k glomerular thrombi and membranoproliferative glomerulonephritis-like lesions [16], myeloma-like kidney [17], direct invasion of the kidneys by lymphoma cells [18], interstitial nephritis [19][20][21], vasculitis [13,22]), nephrocalcinosis [23], and Fanconi syndrome [24].…”

Renal infarction due to polyarteritis nodosa in a patient with angioimmunoblastic T-cell lymphoma: a case report and a brief review of the literature

“…This finding is more common in Hodgkin’s disease rather than non-Hodgkin’s lymphoma. During the clinical course of AITL, proliferative glomerulonephritis [3], minimal-change disease [4,5], A-type amyloidosis [2], acute renal failure [6], immunoglobulin (Ig)M-λ glomerular thrombi, and membranoproliferative glomerulonephritis-like lesions [7], myeloma-like kidney [8], direct invasion by lymphoma cells [9], interstitial nephritis [10,11], vasculitis [12,13], nephrocalcinosis [14], Fanconi syndrome [15] and nephrotic syndrome due to membranous nephropathy (MN) [16] may be rarely observed.To the best of our knowledge, there is only one previous case of AITL associated with polyarteritis nodosa (PAN) [17]. Herein, we report a very unusual complication in AITL, a renal necrotic lesion due to vasculitis with the appearance of PAN, clinically misdiagnosed as renal carcinoma, highlighting the possible pathogenic mechanism.…”