A Case of Anaphylaxis Due to Ibuprofen

Takahama, Hideto; Kubota, Yasuo; Mizoguchi, Masahiro

doi:10.1111/j.1346-8138.2000.tb02178.x

Cited by 16 publications

(8 citation statements)

References 8 publications

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“…Immediate reactions to ibuprofen reported include anaphylaxis [17], with positive skin test or provocation test reported [18][19][20]. Attempts to search for specific IgE antibodies have not been carried out.…”

Section: Propionic Acid Derivativesmentioning

confidence: 97%

Selective immediate hypersensitivity reactions to NSAIDs

Canto

Andreu²,

Fernández³

et al. 2009

Current Opinion in Allergy &Amp; Clinical Immunology

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Section: Propionic Acid Derivativesmentioning

confidence: 97%

Selective immediate hypersensitivity reactions to NSAIDs

Canto

Andreu²,

Fernández³

et al. 2009

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Pirazolones, the most important group inducing selective reactions, are widely used as analgesics in many European, Asian and South American countries [2,4]. Anaphylaxis to ibuprofen has been reported with positive provocation tests in some studies [46][47][48][49], including one case with a positive skin test response. Anthranilic acid derivatives, mainly glafenine, are compounds involved in severe anaphylactic reactions, though glafenine has now been removed from the market [50,51].…”

Section: Selective Immediate Reactionsmentioning

confidence: 99%

Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs

Cornejo-García¹,

Blanca‐López²,

Doña³

et al. 2009

CDM

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NSAIDs are the most important group of drugs involved in hypersensitivity drug reactions, and include heterogeneous compounds with very different chemical structures. These reactions can be IgE dependent (immediate reactions), T cell-mediated (non-immediate), or induced by a non-specific immunological mechanism related with the blocking of the COX-1 enzyme and the shunting to the lipooxygenase pathway (cross-intolerant reactions). Cutaneous symptoms are the most frequent, with ibuprofen, naproxen and diclofenac being common culprit drugs worldwide, although others can be involved because patterns of consumption and exposure rates vary between countries. A very important proportion of immunological reactions are immediate, with urticaria and anaphylaxis being the typical clinical manifestations. Non-immediate reactions comprise a number of heterogeneous entities ranging from mild exanthema to severe TEN or DRESS syndrome, as well as organ-specific reactions such as hepatitis or pneumonitis. Cross-intolerant reactions appear to non-chemically related drugs, and involve respiratory airways, skin or both. In vivo diagnostic tests are based on the capacity of the skin to respond to the culprit drug, but their sensitivity is in many instances rather low. The approach for in vitro testing consists of either detecting specific IgE antibodies or studying the proliferation of T lymphocytes toward the eliciting drug. No appropriate tests are yet available for the in vitro validation of cross-intolerance reactions, although techniques based on the stimulation of basophils have been proposed. Based on these findings, the diagnostic approach is often based on the controlled administration of the drug to assess tolerance. In this work we review current knowledge on hypersensitivity reactions to NSAIDs, including diagnostic approach and genetic studies.

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“…Two main mechanisms are involved: IgE reactions and T cell responses. Concerning the former, the most frequent clinical presentation is anaphylaxis, triggered by pyrazolones and propionic acid derivatives as the main drugs involved . However, anaphylaxis may also occur in multiple NSAID hypersensitivity reactions .…”

Section: Hypersensitivity Induced By Non‐specific Immunological Mechamentioning

confidence: 99%

Advanced phenotyping in hypersensitivity drug reactions to NSAIDs

Ayuso¹,

Blanca‐López

Doña

et al. 2013

Clin Experimental Allergy

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Non-steroidal anti-inflammatory drugs (NSAIDs) are the medications most frequently involved in hypersensitivity drug reactions. Because NSAIDs are prescribed for many conditions, this is a world-wide problem affecting patients of all ages. Various hypersensitivity reactions have been reported, mainly affecting the skin and/or the respiratory airways. The most frequent of these is acute urticaria, which can be induced by several different NSAIDs. Both specific and non-specific immunological pathways have been proposed as underlying mechanisms. This review presents the clinical phenotypes and the drugs involved in NSAID hypersensitivity. Five major clinical syndromes can be distinguished: aspirin-exacerbated respiratory disease (AERD), aspirin-exacerbated cutaneous disease (AECD), multiple NSAID-induced urticaria/angioedema (MNSAID-UA), single NSAID-IgE reactions and single NSAID T cell responses. However, further classification is possible within these five major entities, by detailed descriptions of the clinical characteristics enabling more phenotypes to be defined. This detailed differentiation now seems required in order to undertake appropriate pharmacogenetic studies.

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A Case of Anaphylaxis Due to Ibuprofen

Cited by 16 publications

References 8 publications

Selective immediate hypersensitivity reactions to NSAIDs

Selective immediate hypersensitivity reactions to NSAIDs

Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs

Advanced phenotyping in hypersensitivity drug reactions to NSAIDs

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