A Case of Advanced Primary Thyroid Double-Hit B Cell Lymphoma in Which Complete Remission has been Maintained After High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation Performed During the Second Remission, with a Review of the Literature

Sekiguchi, Y.; Shimada, Asami; Imai, Hidenori; Wakabayashi, Mutsumi; Sugimoto, Keiji; Nakamura, Noriko; Sawada, Tomohiro; Ohta, Yasunori; Komatsu, Norio; Noguchi, Masaaki

doi:10.1007/s12288-013-0312-x

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…DLBCL accounts for up to 70% of all PTLs and represents the most aggressive subtype with 60% of patients exhibiting a rapidly growing compressive enlargement of the neck, disseminate disease, invasion of several organs, systemic symptoms, and poor prognosis …”

Section: Primary Thyroid Lymphoma: From Diagnosis To Treatmentmentioning

confidence: 99%

Lymphomas and thyroid: Bridging the gap

Mancuso

Carlisi

Napolitano

et al. 2018

Hematological Oncology

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The thyroid gland is often involved in the development of neoplastic diseases, including lymphoproliferative disorders. The aim of this paper is to provide a comprehensive overview of the multiple interactions between lymphoma and thyroid. Through an extensive research among the literature, the relationship between lymphomas and thyroid can be established at various levels, and the possible interconnections are here summarized in 5 points: (1) the greater risk of lymphoma development in some thyroid diseases; (2) the primary thyroid lymphoma, with focus on issues related to the diagnosis, differential diagnosis, and treatment; (3) the incidence of thyroid involvement in primitive nodal lymphomas or in extranodal lymphomas of the other sites; (4) thyroid changes after treatment of lymphoma, in relation to the effects of radiation therapy and immuno-chemotherapy; (5) the incidental findings of thyroid changes, on imaging, in patients with lymphoma, without a direct involvement of the gland in malignant disease. In conclusion, issues that until now have been dealt with separately will therefore be analyzed in a unique paper, allowing a global view of the topic and emphasizing the need of a multidisciplinary approach. Future learning areas in this topic mainly relate to rapidly increasing the knowledge of imaging studies together with expanding the armamentarium of novel biological and targeting agents in lymphoma patients.

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Section: Primary Thyroid Lymphoma: From Diagnosis To Treatmentmentioning

confidence: 99%

Lymphomas and thyroid: Bridging the gap

Mancuso

Carlisi

Napolitano

et al. 2018

Hematological Oncology

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“…Such analyses for primary nodal lymphomas have been well documented [15][16][17][18]. For PTL, however, a few sporadic reports have been published [19][20][21][22][23].…”

mentioning

confidence: 99%

Flow cytometric, gene rearrangement, and karyotypic analyses of 110 cases of primary thyroid lymphoma: a single-institutional experience in Japan

et al. 2019

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Ancillary studies for primary nodal lymphomas have been well documented; however, studies of primary thyroid lymphoma (PTL) are limited. Here, we aimed to clarify the clinicopathological, flow cytometric, gene rearrangement, and karyotypic characteristics of PTL by investigation of a large series at a single institute. We performed flow cytometric, IgH rearrangement, and karyotypic analyses of 110 PTL tissues surgically resected at Kuma Hospital between January 2012 and April 2017. All PTLs were of B-cell origin, including mucosa-associated lymphoid tissue lymphoma (MALTL; 89 patients, 80.9%), diffuse large B-cell lymphoma (DLBCL; 18 patients, 16.4%), and follicular lymphoma (FL; three patients, 2.7%). In 96 (87.3%) patients, anti-thyroid antibodies were positive. For flow cytometry using aspirated and resected materials, light chain restriction was observed in 73.7% and 69.2% of examined cases, respectively. Heavy chain JH DNA rearrangement was observed in 65.4% of PTLs (58.1% of MALTL cases, 100% of DLBCL cases, and 100% of FL cases). Chromosomal abnormalities were detected in 49.0% of PTLs, and translocation was most frequently detected (24.0%), followed by addition (20.8%) and trisomy (18.8%). The most frequent (9.4%) karyotype was t(3;14)(q27;q32). Both FLs harbored t(14;18) (q32;q21), and the karyotype was not detected in patients with MALTL and DLBCL. The negative rate for all three examinations was 3.8%. We concluded that thyroid MALTL was cytogenetically different from that in other organs. Our results suggested that pre-operative flow cytometry analysis using aspirated materials was as reliable as that using resected materials.

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“…Among the B‐cell lymphomas, diffuse large B‐cell lymphoma (DLBCL) is the most common subtype and constitutes about 70% of the cases followed by extranodal marginal zone lymphoma and follicular lymphoma 3 . Primary thyroid high‐Grade B‐cell Lymphoma with MYC and BCL2 rearrangements (double‐hit lymphoma) is a highly aggressive and exceedingly rare form of PTL with only a few cases reported in the literature so far 4–6 . High‐Grade B‐cell Lymphoma with MYC and BCL2 and/or BCL6 rearrangements is a distinct cytogenetically defined subtype of mature B‐cell lymphoma that harbors a MYC rearrangement at chromosome 8q24 and a concurrent BCL2 rearrangement at chromosome 18q21 and/or BCL6 rearrangement at 3q27.…”

Section: Figurementioning

confidence: 99%