A Case of Adolescent Pelvic Inflammatory Disease Caused by a Rare Bacterium: Fusobacterium nucleatum

McKinnon, Allison; Lortie, Karine; Fleming, Nathalie

doi:10.1016/j.jpag.2013.02.008

Cited by 11 publications

(4 citation statements)

References 11 publications

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“…F. nucleatum , as a bridging bacterium, transfers critical periodontal pathogens to periodontal infectious sites and recruits and activates local immune cells, which results in tooth-supporting tissue destruction [10, 11]. F. nucleatum has been identified as a high-frequency pathogen in periodontal disease [12] and many other infectious diseases, such as ventriculitis and brain abscesses [13], liver abscesses [14, 15], lung abscesses [16], septicemia-related infections [17], pelvic inflammatory disease [18], and intrauterine infections [19–21]. F. nucleatum attacks host tissues and obstructs the healing of damaged oral tissues by secreting large amounts of ammonia and butyrate [22, 23] and accelerates the initiation and progression of colorectal cancer by promoting tumor cell proliferation [24].…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium nucleatumFacilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-κB Signaling Pathways in Human Gingival Fibroblasts

Kang

Jia

Tang

et al. 2019

Oxidative Medicine and Cellular Longevity

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Fusobacterium nucleatum (F. nucleatum) plays key roles in the initiation and progression of periodontitis. However, the pathogenic effect of F. nucleatum on human oral tissues and cells has not been fully evaluated. In this study, we aimed to analyze the pathogenic effects of F. nucleatum on human gingival fibroblasts (GFs) and clarify the potential mechanisms. RNA-sequencing analysis confirmed that F. nucleatum significantly altered the gene expression of GF as the stimulation time increased. Cell counting and EdU-labeling assays indicated that F. nucleatum inhibited GF proliferation and promoted cell apoptosis in a time- and dose-dependent manner. In addition, cell apoptosis, intracellular reactive oxygen species (ROS) generation, and proinflammatory cytokine production were dramatically elevated after F. nucleatum stimulation. Furthermore, we found that the AKT/MAPK and NF-κB signaling pathways were significantly activated by F. nucleatum infection and that a large number of genes related to cellular proliferation, apoptosis, ROS, and inflammatory cytokine production downstream of AKT/MAPK and NF-κB signaling pathways were significantly altered in F. nucleatum-stimulated GFs. These findings suggest that F. nucleatum inhibits GF proliferation and promotes cell apoptosis, ROS generation, and inflammatory cytokine production partly by activating the AKT/MAPK and NF-κB signaling pathways. Our study opens a new window for understanding the pathogenic effects of periodontal pathogens on the host oral system.

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Section: Introductionmentioning

confidence: 99%

Fusobacterium nucleatumFacilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-κB Signaling Pathways in Human Gingival Fibroblasts

Kang

Jia

Tang

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Unlike other strict anaerobic bacteria, F. nucleatum possess NADH oxidase endowing them with a limited ability to survive in oxygenated environment [ 117 ]. In addition to its implication in periodontal disease [ 118 ], F. nucleatum is capable of systemic dissemination and causing extra-oral infections, such as brain, liver, spleen, and lung abscesses, septicemia related infections, pelvic inflammatory disease, and intrauterine infections [ 119 , 120 , 121 , 122 , 123 , 124 ]. F. nucleatum is equipped with a variety of adhesins that enable it to adhere to various microorganisms.…”

Section: Virulence Factors Of Periodontal Pathogens and Their Associa...mentioning

confidence: 99%

Virulence Factors of the Periodontal Pathogens: Tools to Evade the Host Immune Response and Promote Carcinogenesis

2023

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Periodontitis is the most common chronic, inflammatory oral disease that affects more than half of the population in the United States. The disease leads to destruction of the tooth-supporting tissue called periodontium, which ultimately results in tooth loss if uncured. The interaction between the periodontal microbiota and the host immune cells result in the induction of a non-protective host immune response that triggers host tissue destruction. Certain pathogens have been implicated periodontal disease formation that is triggered by a plethora of virulence factors. There is a collective evidence on the impact of periodontal disease progression on systemic health. Of particular interest, the role of the virulence factors of the periodontal pathogens in facilitating the evasion of the host immune cells and promotion of carcinogenesis has been the focus of many researchers. The aim of this review is to examine the influence of the periodontal pathogens Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), and Fusobacterium nucleatum (F. nucleatum) in the modulation of the intracellular signaling pathways of the host cells in order to evade the host immune response and interfere with normal host cell death and the role of their virulence factors in this regard.

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“…Associations between endometriosis [54], pelvic inflammatory disease [73], and increased time to conception were first identified by Hart et al [58] and later confirmed by Nwhator et al [74]. Periodontitis has the potential to influence pregnancy outcomes in two ways: first, by releasing chronic proinflammatory mediators, or second by allowing periodontal pathogens direct access to the fetal circulation and amniotic fluid [75].…”

Section: Periodontal Health Conception and Concurrent Ammp-8 Levelsmentioning

confidence: 99%

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases

Sorsa

Nwhator

Sakellari

et al. 2022

Front. Oral. Health

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The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75–85% and specificity in the range of 80–90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.

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A Case of Adolescent Pelvic Inflammatory Disease Caused by a Rare Bacterium: Fusobacterium nucleatum

Cited by 11 publications

References 11 publications

Fusobacterium nucleatumFacilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-κB Signaling Pathways in Human Gingival Fibroblasts

Fusobacterium nucleatumFacilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-κB Signaling Pathways in Human Gingival Fibroblasts

Virulence Factors of the Periodontal Pathogens: Tools to Evade the Host Immune Response and Promote Carcinogenesis

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases

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