A Case of Adipsic Hypernatremia Associated with Anomalous Corpus Callosum in Adult with Mental Retardation

Kim, Boo Gyoung; Kim, Ka Young; Park, Youn Jeong; Yang, Ki Hwa; Kim, Jihee; Jung, Hyun-Sam; Nam, Hee Chul; Kim, Young Ok; Yun, Yu Seon

doi:10.3803/enm.2012.27.3.232

Cited by 2 publications

(1 citation statement)

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“…In humans with CCM, adipsia is a very rare clinical feature, and therefore by comparing the morphology of the condition in both species we may find clues about why adipsia is observed in affected dogs. One of the major morphological differences between affected humans and dogs is that when partial agenesis is present in humans it almost always involves the posterior portion of the CC (posterior body and splenium) and interestingly, in the 2 case reports in humans describing adipsia secondary to CCM, the partial CC agenesis present was anterior, similar to that observed in affected adipsic dogs . Because the rostral aspect of the CC lies in very close association with the AV3V region and the rostral cingulate cortex, these findings suggest that these more dorsal regions are important in the pathogenesis of the adipsia observed in dogs with CCM.…”

Section: Discussionmentioning

confidence: 66%

The use of diffusion tractography to characterize a corpus callosum malformation in a dog

Johnson

Barry

Luh

et al. 2018

Veterinary Internal Medicne

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Introduction The pathogenesis of corpus callosum malformations (CCM) is not well defined in the dog because of inherent limitations of structural magnetic resonance imaging (MRI) to evaluate the white matter. We used the advanced neuroimaging technique of tractography to virtually dissect the white matter projections in a dog with a CCM and in a normal control dog. Methods A 9‐month‐old male Coonhound that had a previous structural MRI diagnosis of CCM and a normal control dog underwent anesthesia and 3‐Tesla MRI. Diffusion‐tensor imaging and 3D T1‐weighted and 2D T2‐weighted sequences were acquired. Diffusion data were processed before tensor reconstruction and fiber tracking. Virtual dissections were performed to dissect out the major white matter projections in each dog. Results In the dog with CCM, the corpus callosum exhibited interhemispheric crossing fibers at the level of the splenium and formed longitudinal callosal fasciculi (Probst bundles). In addition, the fornix was small and the cingula enlarged and exhibited increased dorsal connectivity relative to the normal control. Conclusions and Clinical Importance We used tractography to describe a white matter malformation in a dog. The results suggest that, embryologically, formed axons fail to cross midline and instead create Probst bundles.

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Section: Discussionmentioning

confidence: 66%