A Case of Adenocarcinoma of the Small Intestine in a Japanese Patient with Crohn Disease: A Report with Immunohistochemical and Oncogenic Analyses

Uesugi, Hidenaga; Mitomi, Hiroyuki; Sada, Miwa; Takahashi, Hisashi; Kobayashi, Koji; Igarashi, Masahiro; Katsumata, Tomoe; Ihara, Atsushi; Ohtani, Yoshimasa; Ikeda, Shun‐ichi; Okayasu, Isao

doi:10.1080/003655299750024995

Cited by 15 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In CD the p53 expression was found lower than in UC but significantly higher compared with healthy colon. 32 We found relatively high p53 expression in normal samples, but because the DO-7 antibody can bind both the wild and the mutant type of the p53 protein, we believe it is the wild type of the protein that is expressed in normal samples. We also found that the alteration of p53 expression correlated with the progress of the inflammatory process in UC, but not in CD and AC.…”

Section: Discussionmentioning

confidence: 93%

Growth in Epithelial Cell Proliferation and Apoptosis Correlates Specifically to the Inflammation Activity of Inflammatory Bowel Diseases: Ulcerative Colitis Shows Specific p53- and EGFR Expression Alterations

Sípos

Molnár

Zágoni

et al. 2005

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

Based on our results, the alterations of epithelial growth factor receptor and p53 expression show ulcerative colitis specificity, whereas the rate of epithelial apoptosis and proliferation are determined by the histologic activity of the inflammation. The increased epithelial growth factor receptor expression by the lamina propria's mononuclear cells in inflammation may suggest its role as an autoantigen.

show abstract

Section: Discussionmentioning

confidence: 93%

Growth in Epithelial Cell Proliferation and Apoptosis Correlates Specifically to the Inflammation Activity of Inflammatory Bowel Diseases: Ulcerative Colitis Shows Specific p53- and EGFR Expression Alterations

Sípos

Molnár

Zágoni

et al. 2005

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

show abstract

“…Although they have been tested in some tissues, studies on human small intestine, especially on carcinomas, are very limited (Uesugi et al 1999;Bowen et al 2005;Schulmann et al 2005). Schulmann et al (2005) showed that the positive expression of Bax was 59% in 32 cases of small bowel cancer associated with colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma

Gao

Wang

2009

J Histochem Cytochem.

View full text Add to dashboard Cite

S U M M A R Y Human small intestine accounts for 75% of the gastrointestinal (GI) length but for only 1-5% of GI tumors. The reason remains as yet unclearly understood. Our study was designed to examine whether increased apoptosis and expression of related genes/proteins, especially those of the Bcl-2 family, contribute to this difference. For this purpose, 77 samples from patients were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and immunohistochemistry, including 40 cases from normal small intestine (jejunum), 7 cases from jejunum and ileum adenocarcinomas, and 30 cases from normal colon. The results showed that a significantly higher level of enterocyte apoptosis was observed in normal small intestine compared with small intestinal adenocarcinomas and normal colon (median of apoptotic index, 15.2% vs 0.1% and 1.6%, p,0.01). A similar pattern was observed for Bax (expression-positive, 77.5% vs 28.6% and 53.3%, p,0.05) but not for Bcl-2 (42.5% vs 42.9% and 46.7%, p.0.05) or Bax/Bcl-2 ratio (percent of samples having a ratio $1, 45.0% vs 14.3% and 36.7%, p.0.05). In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas. However, more studies are required for a better understanding of these changes. (J Histochem Cytochem

show abstract

“…Mutations in the p53 gene significantly alter its activity of tumor suppression regulation (31) . In patients with CD, increased proliferation of epithelial cells, overexpression of p53 and a reduction in the expression of p21 predispose the small bowel mucosa to dysplasia and the development of carcinoma (40) . Mutations in p53 and c-Ki-ras are frequent in long-term intestinal inflammatory disease, increasing the risk of malignant transformation (14) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease

Romero

Artigiani

Costa

et al. 2008

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -Crohn's disease accompanied by nonspecific or idiopathic ulcerative proctocolitis corresponds to a condition called intestinal inflammatory disease. The immunoexpression of cyclooxygenase 2 (COX-2) in Crohn's disease becomes more marked with progression of the disease and the presence of wild-type p53 suppresses the transcription of COX-2. Aims -To investigate the immunoexpression of cyclooxygenase 1 (COX-1), COX-2 and p53 in Crohn's ileocolitis and to correlated this expression with clinical and histopathological parameters. Methods -Forty-five cases of Crohn's disease, 16 cases of actinic colitis (diseased-control group) and 11 cases without a history of intestinal disease (normal control group) were studied. Hematoxylin-eosin-stained sections were submitted to histopathological analysis and the immunohistochemical expression of COX-1, COX-2 and p53 was evaluated by the streptavidin-biotin-peroxidase method. Results -Sixty percent of the Crohn's disease patients were women and 40% were men, with 75.5% whites and 25.5% non-whites. The disease involved the terminal ileum in 44.5% of cases, ileum in 33.3%, colon in 20% and duodenum-ileum in 2.2%. A significant association was observed between COX-2 immunoreactivity and age ≤40 years. Histopathological analysis of Crohn's disease samples showed mild or moderate crypt distortion (57.8% and 35.6% of cases), atrophy (6.6%), mild, moderate and marked chronic inflammation (46.7%, 26.7% and 20%), acute inflammatory activity (93.3%), ulceration (24.4%), mucin depletion (37.8%), Paneth's cells (24.4%), intraepithelial lymphocytes (93.3%), and subepithelial collagen (6.7%). In the CD group, COX-1 immunoreactivity in epithelial and inflammatory cells was observed in 26.7% and 22.2% of cases, respectively.

show abstract

A Case of Adenocarcinoma of the Small Intestine in a Japanese Patient with Crohn Disease: A Report with Immunohistochemical and Oncogenic Analyses

Cited by 15 publications

References 14 publications

Growth in Epithelial Cell Proliferation and Apoptosis Correlates Specifically to the Inflammation Activity of Inflammatory Bowel Diseases: Ulcerative Colitis Shows Specific p53- and EGFR Expression Alterations

Growth in Epithelial Cell Proliferation and Apoptosis Correlates Specifically to the Inflammation Activity of Inflammatory Bowel Diseases: Ulcerative Colitis Shows Specific p53- and EGFR Expression Alterations

Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma

Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease

Contact Info

Product

Resources

About