A Case of Adeno-endocrine Cell Carcinoma of the Gallbladder.

Yokoyama, Yoshinobu; Saito, Fumikazu; Tsuzawa, Toyokazu; Miura, Fumio; Saito, J

doi:10.5833/jjgs.31.2250

Cited by 4 publications

(2 citation statements)

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“…As a result, chemotherapy is applied after the initial diagnosis of small-cell carcinoma. Sabanathan et al and Yokoyama et al applied cisplatin plus etoposide and cyclophosphamide plus doxorubicin plus vincristine to adenoendocrine carcinomas [12,13] according to the regimen of small-cell lung carcinoma, and achieved several good results. Our patient received no chemotherapy because of his old age, above 80 years.…”

Section: Discussionmentioning

confidence: 96%

Adenoendocrine cell carcinoma of the extrahepatic bile duct: a case report and review of the literature

Masui

Doi

Kawaguchi

et al. 2011

Clin J Gastroenterol

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Extrahepatic bile duct cancer with an endocrine cell component has rarely been reported. We report here on a case of adenoendocrine cell carcinoma in the middle bile duct. An 82-year-old man was admitted to hospital for jaundice and anorexia. Computed tomography and magnetic resonance imaging examination showed a papillary low-density mass in the middle bile duct. Endoscopic retrograde cholangiography showed obstruction of the bile duct, and blushing cytology of the bile duct revealed an adenocarcinoma. We resected the extrahepatic bile duct with regional lymph node dissection. A pathological examination revealed a neuroendocrine component showing small cytoplasmic cells with hyperchromatic nuclei and a rosette-like structure in the middle of the tumor. In the peripheral mucosal region, there was a well-differentiated adenocarcinoma composed of columnar and cuboidal epithelial cells with clear and slightly granular eosinophilic cytoplasm. Immunohistochemical analysis showed positive staining for CD56, following the diagnosis of adenoendocrine cell carcinoma. The Ki-67 rate was >30% suggesting a small-cell endocrine carcinoma. The adenocarcinoma component infiltrated into the endocrine component, and some of the endocrine component was positive for cytokeratin, suggesting transdifferentiation of the adenocarcinoma into the endocrine component rather than originating from the common precursor cell. The patient experienced liver metastasis 3 months after the operation and died 6 months after the operation. Adenoendocrine tumor of the bile duct is extremely rare and adjuvant chemotherapy is necessary according to the malignant potential of the neuroendocrine tumor rather than the adenocarcinoma.

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Section: Discussionmentioning

confidence: 96%

Adenoendocrine cell carcinoma of the extrahepatic bile duct: a case report and review of the literature

Masui

Doi

Kawaguchi

et al. 2011

Clin J Gastroenterol

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“…As far as we can determine, 18 cases of adeno‐endocrine cell tumor of the gallbladder have been reported, including our case (Table 1). 1, The age range was 46 to 81 years (mean, 67 years). There were 7 men and 11 women.…”

Section: Discussionmentioning

confidence: 99%

Adeno-endocrine cell carcinoma of the gallbladder

Eriguchi

Aoyagi

Noritomi

et al. 2000

Journal of Hepato-Biliary-Pancreatic Surgery

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We encountered a rare case of adeno-endocrine cell carcinoma of the gallbladder in an 81-year-old woman. Imaging study revealed a common bile duct stone. Endoscopic sphincterotomy was performed, and the stone was extracted successfully. Thereafter, cholecystectomy was performed. A papillary tumor was found in the neck of the gallbladder. Histologically, the tumor consisted of two components, well differentiated adenocarcinoma and endocrine cell carcinoma. However, no clinical signs of tumor hormonal activity were observed. The tumor cells in the area of the endocrine cell carcinoma were small and round. Histochemical studies of these tumor cells were positive for chromogranin A and Grimelius silver impregnation. The tumor cells in the area of the adenocarcinoma were well differentiated adenocarcinoma and included goblet-type cells with a tubular structure or solid growth pattern. These adenocarcinoma cells stained positively for Alcian blue and periodic acid-Schiff, and both types of tumor cells stained positively for carbohydrate antigen and carcinoembryonic antigen. It was suggested that the histogenesis of the endocrine cell carcinoma of the gallbladder was closely related to that of the adenocarcinoma.

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