A Case of Acute Toxic Hepatitis induced by brief exposure to Dimethylformamide

Roh, Jong Rae; Sohn, Jin Gun; Kim, Jin Ha; Park, Sun Ja

doi:10.35371/kjoem.2005.17.2.144

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…After several outbreaks of toxic hepatitis after being exposed to dimethylformamide, which is used to produce synthetic fiber and leather, a study was conducted in Korea in 1991 ( 27 ). In 1995, a suspicious case of fulminant hepatitis that was attributable to DMF was reported ( 28 ) followed by reports of toxic hepatitis in 1999, 2005, and 2006 ( 29 , 30 , 31 ). On September 27, 2012, approximately 8-12 tons of 100% anhydrous hydrogen fluoride were released for approximately 8 hr while a tank transport vehicle was being moved ( 32 ).…”

Section: Resultsmentioning

confidence: 99%

Compensation for Occupational Diseases by Chemical Agents in Korea

et al. 2014

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Investigation into the frequency of compensation for occupational diseases (ODs) caused by hazardous chemicals revealed an important opportunity for the improvement and further development of occupational health and safety systems in Korea. In response to concerns after outbreaks of disease due to chemical exposure, specific criteria for recognition of ODs were established and included in the Enforcement Decree of the Labor Standard Act (LSA) and the Industrial Accident Compensation Insurance Act (IACIA) on June 28, 2013. However, the original versions of the LSA and IACIA contain several limitations. First, the criteria was listed inconsistently according to the symptoms or signs of acute poisoning. Second, all newly recognized hazardous chemicals and chemicals recognized as hazardous by the International Labor Organization (ILO) were not included in the LSA and IACIA. Although recent amendments have addressed these shortcomings, future amendments should strive to include all chemicals listed by the ILO and continuously add newly discovered hazardous chemicals as they are introduced into the workplace.Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Compensation for Occupational Diseases by Chemical Agents in Korea

et al. 2014

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“…Table 2 summarizes the occupational liver diseases reported in the Annals of Occupational and Environmental Medicine until recently. 8 9 13 14 15 16 17 18 Cases of toxic hepatitis caused by various xlink:types of organic solvents were reported in Korea, and there were 2 cases of toxic hepatitis caused by chloroform. The first reported case was suspected chloroform-induced hepatotoxicity in a laboratory engineer in 2012, 8 and the second case was hepatotoxicity of the 2 patients who worked in the clean room at a medical endoscopic manufacturer in 2014.…”

Section: Discussionmentioning

confidence: 99%

A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process

Hwang

Kim

2022

Ann Occup Environ Med

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Background Several cases of chloroform-induced hepatotoxicity have been reported worldwide, but only 2 cases have been reported in Korea. We encountered a case of toxic hepatitis due to chloroform exposure in February 2022 and report the diagnosis process and clinical findings. Case presentation A 38-year-old employee in charge of the coating after washing (degreasing) at an automotive parts manufacturer complained of jaundice and was diagnosed with acute toxic hepatitis. After the initial diagnosis, he continued to work, his symptoms worsened, and he was hospitalized for 8 days. Liver ultrasonography (elastography) revealed acute hepatitis. The washing agent contained chloroform, which was not listed on the materials safety data sheet, and the concentrations of chloroform in the workplace were up to 4.7 times the time-weighted average. Conclusions This patient showed typical toxic hepatitis with chloroform; further follow-up studies are required. Both employers and workers should be aware of information on toxic substances and take precautions to avoid exposure.

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The potential health risks of N,N‐dimethylformamide: An updated review

Hong,

Zhang,

Sun

et al. 2024

J of Applied Toxicology

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N,N‐dimethylformamide (DMF) is a universally used industrial material with exponential growth in production and consumption worldwide. The frequently reported occupational DMF poisoning cases in some countries and the gradually recognized unavoidable health risks to the general population highlight that DMF should still be a matter of concern. Previous studies have demonstrated that the liver is the primary target organ of DMF exposure and multiple mechanisms have been revealed. However, most of these studies investigate the detrimental effects of acute and subacute DMF exposure, while the effects of chronic DMF exposure are rarely studied. Furthermore, the key mechanism for the acute hepatotoxicity of DMF remains to be elucidated. Future research may focus on the identification of efficient preventive measures against the toxicity of DMF to occupational workers, the investigation of the detrimental effects of DMF at environmentally relevant doses, and the studies on the elimination and recycling of DMF in industrial wastes. Herein, we present an updated review of the metabolism of DMF, the biomarker of DMF exposure, underlying molecular mechanisms of DMF‐induced hepatotoxicity, and the toxicity of DMF to both occupational workers and general populations and discuss the possible directions in future studies.

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A Case of Acute Toxic Hepatitis induced by brief exposure to Dimethylformamide

Cited by 5 publications

References 13 publications

Compensation for Occupational Diseases by Chemical Agents in Korea

Compensation for Occupational Diseases by Chemical Agents in Korea

A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process

The potential health risks of N,N‐dimethylformamide: An updated review

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