A case of acute respiratory distress syndrome responsive to methylene blue during a carcinoid crisis

Diepen, Sean van; Sobey, Alan; Lewanczuk, Richard; Singh, Gurmeet; Sidhu, Surita; Zibdawi, Mohamad; Mullen, John C.

doi:10.1007/s12630-013-0026-4

Cited by 14 publications

(5 citation statements)

References 17 publications

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“…(Ahlman et al, 1987;Marsh et al, 1987;Roy et al, 1987;Ahlman et al, 1988a;Ockert and White, 1988;Darby et al, 1990;Debas and Mulvihill, 1994;Deguchi et al, 1994;Parry et al, 1996;Pekarek et al, 1997;Balestrero et al, 2000;Janssen et al, 2000;Kharrat and Taubin, 2003;Zimmer et al, 2003;Koopmans et al, 2005;Davi et al, 2006;Majeed et al, 2007;Papadogias et al, 2007;De Keizer et al, 2008;McPherson et al, 2009;Sinha et al, 2009;Yazbek-Karam et al, 2009;Fujie et al, 2010;Morrisroe et al, 2012;Raikhelkar et al, 2012;Shah et al, 2012;Massimino et al, 2013;van Diepen et al, 2013) The prophylactic usage of SSTA was diverse between different studies varying from long acting SSTA to continuous somatostatin infusion. Of the 28 patients with known demographic information, 17 cases (60.7%) were men and 11 cases (39.3%) were women.…”

Section: Resultsmentioning

confidence: 99%

Somatostatin Analogues Do Not Prevent Carcinoid Crisis

Guo

Tang²

2014

Asian Pacific Journal of Cancer Prevention

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Background: Carcinoid crisis is a life-threating syndrome of neuroendocrine tumors (NETs) characterized by dramatic blood pressure fluctuation, arrhythmias, and bronchospasm. In the era of booming anti-tumor therapeutics, this has become more important since associated stresses can trigger carcinoid crisis. Somatostatin analogues (SSTA) have been recommended for prophylactic administration before intervention procedures for functioning NETs. However, the efficacy is still controversial. The aim of this article is to review efficacy of SSTA for preventing carcinoid crisis. Materials and Methods: PubMed, Cochrane Controlled trials Register, and EMBASE were searched using 'carcinoid crisis' as a search term combining terms with 'somatostatin'; 'octreotide'; 'lanreotide' and 'pasireotide' until December 2013. Results: Twenty-eight articles were retrieved with a total of fifty-three unique patients identified for carcinoid crisis. The most common primary sites of NETs were the small intestine and respiratory tract. The triggering factors for carcinoid crisis included anesthesia/ surgery (63.5%), interventional therapy (11.5%), radionuclide therapy (9.6%), examination (7.7%), medication (3.8%), biopsy (2%) and spontaneous (2%). No randomized controlled trials (RCTs) were identified and two case-control studies were included to assess the efficacy of SSTA for preventing carcinoid crisis by meta-analysis. The overall pooled risk of perioperative carcinoid crisis was similar despite the prophylactic administration of SSTA (OR 0.44, 95% CI: 0.14 to 1.35, p=0.15). Conclusions: SSTA wasnot helpful for preventing carcinoid crisis based on a meta-analysis of retrospective studies. Attentive monitoring and careful intervention are essential. Future studies with better quality are needed to clarify any effect of SSTA for preventing carcinoid crisis.

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Section: Resultsmentioning

confidence: 99%

Somatostatin Analogues Do Not Prevent Carcinoid Crisis

Guo

Tang²

2014

Asian Pacific Journal of Cancer Prevention

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“…The role of telotristat ethyl in other symptoms of CS (e.g., flushing) and in carcinoid crisis also deserves further study. In both flushing and carcinoid crisis, serotonin is just one of the circulating hormones which may contribute to these features [50]. The available studies of telotristat ethyl were not powered to detect changes in flushing though there was a statistically significant improvement in flushing in a Phase II trial [46] and a statistically nonsignificant, dose-dependent, trend to improved flushing in a Phase III trial [47].…”

Section: Discussionmentioning

confidence: 99%

Telotristat Ethyl: A Novel Agent for the Therapy of Carcinoid Syndrome Diarrhea

Dillon

Chandrasekharan

2018

Future Oncol.

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Carcinoid syndrome (CS), characterized by diarrhea and flushing, is present in 20% of patients with neuroendocrine tumors at diagnosis and becomes more frequent with progression. The diarrhea of CS is caused mainly by tumoral secretion of serotonin. It may not be fully controlled by somatostatin analogs, the currently indicated drugs for symptomatic relief. Telotristat ethyl is a novel inhibitor of tryptophan hydroxylase, the rate-limiting enzyme in serotonin biosynthesis. Administration of the drug decreases diarrhea in patients with CS. Telotristat ethyl was approved in February 2017 (USA) and September 2017 (European Commission) for the treatment of CS diarrhea in adults inadequately controlled by somatostatin analog alone. This drug is expected to greatly improve the health and quality of life of patients with CS diarrhea.

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“…Aunque se ha descrito una relación del síndrome carcinoide con la aparición de crisis carcinoide ante la exposición de una condición de estrés, el no lograr demostrar prevención con análogos de la somatostatina en todas las oportunidades, como en el caso expuesto, apoya la posibilidad de que puede haber otros mecanismos que predisponen a estas crisis [11]. También se ha reportado el uso de azul de metileno para el tratamiento del choque y del edema pulmonar no cardiogénico desencadenado por una crisis carcinoide, dado que este bloquea de manera competitiva la unión de la enzima óxido nítrico sintetasa al guanilato ciclasa, relacionado de alguna forma con la acción de la bradiquinina, sin embargo, los estudios no tienen evidencia científica suficiente para generar recomendaciones al respecto [15,17].…”

Section: Caso Clínicounclassified

Crisis carcinoide como una causa poco frecuente de choque distributivo

Benítez-Patiño

Tibavizco-Palacios

2022

Med. Lab.

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Los tumores neuroendocrinos son neoplasias que suelen tener un comportamiento clínico maligno, son provenientes de células entero cromafines y/o células productoras de gastrina. Según su origen anatómico, se clasifican en tumores del intestino anterior (comprometen estómago, duodeno, pulmones y páncreas), intestino medio (parte distal del duodeno) e intestino posterior (colon transverso hasta el recto). El síndrome carcinoide, presente en la mitad de los casos al momento del diagnóstico, se caracteriza por desencadenar episodios de diarrea, taquicardia, hipotensión, rubor (por el desarrollo de telangiectasias), y según la gravedad, valvulopatías cardiacas. Por otro lado, la crisis carcinoide, una complicación infrecuente, está relacionada con episodios de choque, que cuando ocurren son consecuencia de la liberación en la circulación sistémica de aminas vasoactivas, posterior a un evento desencadenante. A continuación, se presenta el caso de un paciente masculino con antecedente de un tumor neuroendocrino de intestino delgado, quien luego de ser llevado a embolización de metástasis hepáticas, presentó una crisis carcinoide, y finalmente un choque distributivo refractario a tratamientos convencionales, incluyendo octreotide y vasopresores, que culminó con la muerte del paciente. Se realiza la discusión del caso clínico y la presentación de la literatura disponible, donde se describe la epidemiología, patogénesis, diagnóstico, clínica y tratamiento de esta entidad.

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A case of acute respiratory distress syndrome responsive to methylene blue during a carcinoid crisis

Cited by 14 publications

References 17 publications

Somatostatin Analogues Do Not Prevent Carcinoid Crisis

Somatostatin Analogues Do Not Prevent Carcinoid Crisis

Telotristat Ethyl: A Novel Agent for the Therapy of Carcinoid Syndrome Diarrhea

Crisis carcinoide como una causa poco frecuente de choque distributivo

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