A Case of Acute Myopericarditis Associated With<i>Mycoplasma Pneumoniae</i>Infection in a Child

Choi, Du Young; Oh, You-Chang; Kim, Jong Duck; Yu, Seung‐Hun

doi:10.4070/kcj.2012.42.10.709

Cited by 17 publications

(11 citation statements)

References 19 publications

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“…Mycoplasma pneumoniae pneumonia (MPP) is considered as a benign and self-limiting disease. However, it has been found that some children may progress to refractory Mycoplasma pneumoniae pneumonia (RMPP) after being treated with sufficient and long-term macrolide antibiotics in timely [ 2 ], which often leads to pulmonary necrosis and pleural effusion, which may not only be difficult to treat and costing, but also leave sequelae such as bronchiectasis, necrotizing pneumonia, bronchiolitis obliteransa and so on [ 3 – 7 ], thus affect the quality of life. Over-immune response of host plays an important role in the development of RMPP [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of refractory mycoplasma pneumoniae pneumonia in children treated with glucocorticoid pulse therapy

et al. 2021

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Background To observe the effect of corticosteroids in the treatment of children with refractory Mycoplasma pneumoniae pneumonia (RMPP) under different doses, to summarize the clinical features of children treated with glucocorticoid pulse therapy. Methods The clinical data of 125 children with RMPP hospitalized in Tianjin Children’s Hospital from September 2018 to October 2019 were retrospectively analyzed. They were divided into two groups according to the dose of hormone. Compare the clinical features, laboratory findings, and imaging between the two groups, and use meaningful related indicators as ROC curves to find reference indicators for pulse therapy. Results (1) The median age of the group II was older than that of the group I(P < 0.05). (2) We found more severe presentations, higher incidence of extra-pulmonary complications and more serious radiological findings in group II, which needed oxygen more often, higher the hormone, higher usage rate of gamma globulin, higher usage rate of bronchoscopy, and higher incidence of plastic bronchitis(P < 0.05). (3) WBC, CRP, LDH, FER, D-D dimer, APTT, TT, PCT, IL-6 and the percentage of neutrophils in peripheral blood in Group II were higher than those in Group I(P < 0.05). (4) In ROC curve analysis, CRP, LDH, FER, and neutrophils of leukocyte classification were independent related factors that could be used as valuable predictors of methylprednisolone pulse therapy for RMPP in children. The cut-off values were CRP44.45 mg/L, LDH590IU/L, FER411ng/L, and neutrophils in leukocyte classification were 73.75%, respectively. Conclusion CRP ≥ 44.45 mg/L, LDH ≥ 590 IU/L, FER ≥ 411 ng/L, neutrophil≥73.75%, lung consolidation, and pleural effusion may be predictors that guide the treatment of RMPP with pulse dose of GC.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics of refractory mycoplasma pneumoniae pneumonia in children treated with glucocorticoid pulse therapy

et al. 2021

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“…However, carditis due to Mycoplasma pneumoniaeis more frequent in adult population. Some cases of M. pneumoniae carditis are described in the literature: they concern adolescent and adult subjects [9][10][11][12] and more rarely children [13,14]. As a matter of fact, in a review of Paz and Potasman of 21 cases of Mycoplasma associated carditis, the mean age was 33 years [15].…”

Section: Discussionmentioning

confidence: 99%

Carditis as unrecognized extra-pulmonary complication of Mycoplasma pneumoniae infection in adults: a case report

Tiseo

Russo

Falcone

2017

Inter. jour. antoboit. and probiot.

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A 44 years old Caucasic male was admitted to the Emergency Department for the sudden onset of chest pain. The pain started three hours before admission, was described as oppressive, localized in the left breast area, radiating to the left arm, not exacerbated with cough or inspiration, constant with pressure over the left chest. The intensity rating was initially 10 out of 10, but it gradually decreased within a few hours spontaneously. Furthermore the patient referred weakness, not productive cough and fever of 38.7 °C in the previous week. No significant risk factors for cardiovascular disease were identified, but family history of early coronary artery disease was reported. He denied any substance use. His medical history was negative, except for a previous facial paralysis due to Herpes Zoster infection when he was twenty years old. Patient did not take any drugs. At the admission, blood pressure was 120/80 mm Hg, respiratory rate 18/min, heart pulse rate 100 beats/min and oxygen saturation of 96-98 percent on room air. Cardiac examination revealed normal S1S2, no murmur, no rub, gallop or distended jugular venous pulse. No lower limb edema was evident. Chest examination revealed areduction of tactile fremitus, flatness to percussion and presence of inspiratory crackles in the left basal area. Abdomen exami nation was normal. Electrocardiogram (EKG) (Figure 1) showed sinus tachycardia and non-specific alteration of Carditis as unrecognized extra-pulmonary complication of mycoplasma pneumoniae infection in adults: a case report Abstract A 44 years old man admitted to the hospital with fever and sudden onset of severe oppressive chest pain localized in the left breast area, radiating to the left arm. Examination revealed blood pressure 120/80 mm Hg, respiratory rate 18/min, heart pulse rate 100 beats/min, oxygen saturation (SpO 2) of 96-98 % on room air, flatness to percussion and presence of inspiratory crackles in the left basal area. EKG showed sinus tachycardia and non-specific alteration of repolarization in the anterolateral area of left ventricle. Troponin I and CK-MB, CRP and erythrosedimentation rate were considerably elevated. Chest radiograph performed at the admission revealed left basal consolidation with an effusion, suggesting pneumonia. On the basis of this data atypical pneumonia with cardiac complication was suspected and serum titers for respiratory viruses and atypical microorganism was performed. Antibodies (IgM) to M. pneumoniae were positive with high titer. Cardiac MRI was performed and showed tissue edema areas and multiple «late enhancement» myocardial areas on the anterolateral wall of left ventricle. Pneumonia and carditis due to Mycoplasma pneumoniae were successfully treated with clarithromycin 500 mg twice daily and ceftriaxone 2 g one daily for fifteen days.

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“…Review of the literature shows very few cases of liver involvement secondary to Mycoplasma. One case of hepatitis without pneumonia was reported from Korea [6,7]. In addition, Mycoplasma associated encephalitis has been reported in two children after viral upper respiratory infection.…”

Section: Vascular Occlusionmentioning

confidence: 99%

A Rare Case of Extra-Pulmonary Manifestation of Mycoplasma pneumoniae

Tabb¹,

Gunasekaran²,

Kothari³

et al. 2019

Clin Pediatr

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Background and aim: Mycoplasma pneumoniae is one of the many organisms causing pneumonia in children. It commonly presents with pulmonary manifestations however uncommonly infection with M. pneumoniae causes extra-pulmonary manifestations. Involvement of liver is one of such rare extra-pulmonary manifestations of M. Pneumoniae. Direct and indirect hits along with vascular occlusion leading to liver injury have been postulated to be the cause of liver involvement. Case presentation: A 10-year-old African American boy with mild obstructive sleep apnea, chronic migraine, gastroesophageal reflux presented with 5-day history of rash, fever, emesis, dark urine, diarrhea, thrush, decreased oral intake and abdominal pain. The rash didn't improve with diphenhydramine at home. Patient was initially tachycardic, tachypneic, and febrile to 39.6°C. Initial physical examination revealed, scleral icterus, maculopapular erythematous diffuse rash all over the body, bilateral conjunctivitis, with right upper quadrant tenderness but no organomegaly. Initial laboratory results showed moderate transaminitis, along with elevated bilirubin, however initial imaging study was found to be normal. The patient over the course of his admission continued to spike high fevers and WBC counts continued to rise. Conclusion: Mycoplasma pneumoniae is often thought to cause pulmonary disease and very few cases have been presented with extra-pulmonary manifestations. Early diagnosis and initiation appropriate therapy improves outcome and decreases the incidence of extra-pulmonary manifestations.

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A Case of Acute Myopericarditis Associated WithMycoplasma PneumoniaeInfection in a Child

Cited by 17 publications

References 19 publications

Clinical characteristics of refractory mycoplasma pneumoniae pneumonia in children treated with glucocorticoid pulse therapy

Clinical characteristics of refractory mycoplasma pneumoniae pneumonia in children treated with glucocorticoid pulse therapy

Carditis as unrecognized extra-pulmonary complication of Mycoplasma pneumoniae infection in adults: a case report

A Rare Case of Extra-Pulmonary Manifestation of Mycoplasma pneumoniae

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