A Case of Acute Motor and Sensory Axonal Neuropathy Following Hepatitis A Infection

Abstract

Acute motor and sensory axonal neuropathy (AMSAN) are recently described subtypes of Guillain-Barre syndrome characterized by acute onset of distal weakness, loss of deep tendon reflexes, and sensory symptoms. A 21-yr-old male was transferred to our hospital due to respiration difficulties and progressive weakness. In laboratory findings, immunoglobulin M antibodies against hepatitis A were detected in blood and cerebrospinal fluid. The findings of motor nerve conduction studies showed markedly reduced amplitudes of compound muscle action potentials in bilateral peroneal, and posterior tibial nerves, without evidence of demyelination. Based on clinical features, laboratory findings, and electrophysiologic investigation, the patient was diagnosed the AMSAN following acute hepatitis A viral infection. The patient was treated with intravenous immunoglobulin and recovered slowly. Clinicians should consider this rare but a serious case of AMSAN following acute hepatitis A infection.

Pulse‐steroid therapy in a 37‐year‐old man with acute motor and sensory axonal neuropathy: A case report

“…Acute motor and sensory axonal neuropathy (AMSAN) is a rare variant of GBS characterized by acute‐onset distal weakness, diminished or absent deep tendon reflexes, and sensory symptoms. The prevalence of AMSAN is relatively small: the variant accounts for <10% of all cases of GBS . Campylobacter jejuni , cytomegalovirus, and Epstein‐Barr virus infection are the most common triggers of GBS, and in particular AMSAN …”

“…The prevalence of AMSAN is relatively small: the variant accounts for <10% of all cases of GBS. 2 Campylobacter jejuni, cytomegalovirus, and Epstein-Barr virus infection are the most common triggers of GBS, and in particular AMSAN. 3 Guillain-Barré syndrome is diagnosed on the basis of a clinical evaluation, cerebrospinal fluid (CSF) findings, and the results of nerve conduction studies.…”

Acute Axonal Senzoriomotor Polyneuropathy in Systemic Lupus Erythematosus (Sle) Hemodialysed Patient

“…AMSAN, axonal subtypes of GBS cases, preceded by Campylobacter jejuni enteritis are reported in the literature. [3]. Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Haemophilus influenzae (H. influenzae) and Hepatitis A infection could led also to AMSAN.…”

“…Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Haemophilus influenzae (H. influenzae) and Hepatitis A infection could led also to AMSAN. The exact pathogenesis by which these cause the disease is not clear [3][4][5][6].…”

Antimicrobial Nanostructures for Neurodegenerative Infections

“…EpsteineBarr virus and West Nile virus do not play a role in the development of peripheral neuropathy. Viral infections are able to affect the nervous system and cause severe damage to the sensory and motor nerves leading to sharp and severe pain (Chikakiyo et al, 2005;Jo et al, 2013;Kokotis et al, 2013). Moreover, infection with West Nile virus, which occurs through mosquitoes, causes severe motor neuropathy along with various forms of inflammatory neuropathies.…”