A case of acute liver failure induced by hepatitis E virus in a patient with chronic alcoholic liver dysfunction

Kobayashi, Tomoe; Tanaka, Shugo; Yokoyama, Tetsuji; Matsumoto, Shogo; Sarashina, Koichiro; Kawahata, Shuhei

doi:10.2957/kanzo.61.374

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these 2 patients, 1 patient succumbed due to the rupture of hepatocellular carcinoma ( 36 ). Another study reported that a 49-year-old male with excessive alcohol consumption and acute HEV genotype 4 infection developed acute liver failure ( 37 ). Thus, HEV genotype 3 or HEV genotype 4 is also a key acute insult in ACLF.…”

Section: Discussionmentioning

confidence: 99%

Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report

Kanda,

Arima,

Sasaki‑Tanaka

et al. 2024

Med Int

View full text Add to dashboard Cite

Hepatitis E virus (HEV) infection occasionally causes acute-on-chronic liver failure in patients with alcohol-associated cirrhosis. These reports have been published mainly from highly HEV genotype 1-endemic countries. The present study describes the case of a patient with severe HEV genotype 3b infection and alcohol-associated liver disease. A male patient in his 70s who consumed alcohol, and who had begun consuming alcohol at the age of 12, had high levels of alanine aminotransferase (ALT) and total bilirubin. The peak levels of ALT and total bilirubin were 1,067 IU/l and 26.3 mg/dl, respectively. A computed tomography scan revealed an atrophic liver. Upon admission, both anti-HEV immunoglobulin A and HEV RNA were positive, and his HEV was genotype 3b. He also had chronic kidney disease, as his estimated glomerular filtration rate was <45 ml/min/1.73 m 2 , and ribavirin could not be used. The abnormal levels of the liver function parameters of the patient gradually improved due to conservative treatment, and he was discharged on day 43. On the whole, the present study demonstrates that careful attention should be paid to patients with viral hepatitis, including hepatitis E, when alcohol-associated liver disease is present. Novel anti-HEV drugs need to be developed for severe HEV infections with chronic kidney disease.

show abstract

Section: Discussionmentioning

confidence: 99%