A case of acute hemolytic transfusion reaction due to anti-Di^aantibody -A case report-

Abstract

Many medical institutions in Korea have recently been performing an antibody screening test as one of the essential elements of a pre-transfusion test. The Dia antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. The frequency of the Dia antigen among the Korean population is estimated to be 6.4-14.5%. But in Korea, a screening panel of cells from abroad without Dia positive cells has been commonly used when a patient has an unexpected antibody screening test. Here we report a case of acute hemolytic transfusion reaction due to Anti-Dia antibody. To prevent other transfusion reaction by anti-Dia antibody, addition of Dia positive cells as unexpected antibody screening test is recommended.

Frecuencia del antígeno y aloanticuerpos del sistema Diego en donantes de sangre

“…El tamizaje de anticuerpos irregulares o aloanticuerpos en donantes de sangre está dentro de las directrices de los estándares para bancos de sangre 12 , sin embargo las células comerciales utilizadas para este fin no detectan aloanticuerpos del sistema Diego 13,14 , debido a que estas células son preparadas en países donde los antígenos Diego no son comunes, por lo tanto no es posible encontrar células con este fenotipo 2 . Por ello es necesario introducir estos reactivos en países con prevalencia de estos antígenos.…”

“…Muchas veces la aloinmunización por antígenos eritrocitarios del sistema Diego pasa desapercibida, y no es hasta que se presenten reacciones transfusionales o hemólisis fatales en neonatos cuando se determina su existencia en los pacientes involucrados, abriendo así la duda sobre qué porcentaje de la población se encuentra expuesta a estos antígenos de manera desconocida [3][4][5] . En Ecuador, la información de la presencia de antígenos y aloanticuerpos del sistema Diego se desconoce, y más aún cuando se trata sobre estudios de prevalencia de dicho sistema, sobre la cual la información resulta casi inexistente.…”

Fatal Acute Hemolytic Transfusion Reaction due to Anti-Wra

“…This case highlights the non-detection of antibodies to low-frequency blood group antigens as a potential limitation of the immediate-spin or computer crossmatch [18,19,20]. The incompatibility of patient and donor would have been detected if a full IAT crossmatch had been used.…”

Revisiting the Pre-transfusion Test: A Case of Acute Hemolytic Transfusion Reaction due to Multiple Alloantibodies of Anti-E, Anti-c, Anti-Jkb

“…급성 용혈수혈반응은 수혈 중이나 수혈 24시 간 이내에 일어나며 발열, 오한, 혈뇨, 소변량 감 소 등의 증상을 보이며 섬유소원 감소, 합토글로 빈 감소, 빌리루빈 증가 등의 검사소견을 보이게 된다 [1]. 사무적인 착오나 오류에 의한 ABO 부적 합에 의해 발생하는 경우가 가장 흔한 원인이지 만 비예기항체에 의해 발생하는 예도 다수 보고 되어 있다 [2][3][4]. 그렇지만 교차시험 적합혈액을 [9].…”