A Case of Acute Generalized Exanthematous Pustulosis Possibly Induced by Ritodrine

Won, June Ho; Yun, Sook Jung; Kim, Seong‐Jin; Lee, Seung−Chul; Won, Young Ho; Lee, Jee Bum

doi:10.5021/ad.2009.21.3.323

Cited by 3 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature reports that drug-related AGEP develops in less than 24 hours1,5. There are also reports in the literature of cases developing after acute viral infections and spider bites.…”

Section: Discussionmentioning

confidence: 99%

“…The lack of hyperplasia and achantosis are important when differentiating AGEP from pustular psoriasis2,4,5. The presence of histopathological findings typical for AGEP is helpful for making different diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…In 1980, AGEP was evaluated for the first time as a separate entity 2 . It can be differentiated from pustular psoriasis by its histopathologic characteristics, its short course, the lack of psoriasis in the anamnesis and the involvement mostly of flexor surfaces 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Drugs (particularly antibiotics) are held to be mainly responsible for this etiopathogenesis. The literature reports that drug-related AGEP develops in less than 24 hours 1 , 5 . There are also reports in the literature of cases developing after acute viral infections and spider bites.…”

Section: Discussionmentioning

confidence: 99%

“…The disease is generally self-limited when the causative factor is eliminated; and cure can be ensured with a short-term systemic steroids and a symptomatic treatment 5 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

et al. 2014

View full text Add to dashboard Cite

Acute generalized exanthematous pustulosis (AGEP) is a severe and rare eruption that develops mostly from factors related to drugs. It is characterized by a fever and a pustular eruption on the erythematous skin with an acute onset and without follicular localization. Etiopathogenesis has not yet been fully explained. Although it is similar to pustular psoriasis, its clinical, historical and histopathological characteristics are different. In this article, we present a case of AGEP associated with tigecycline that developed in a patient followed up in the intensive care unit for three months with an intra-abdominal injury after a trauma and Acinetobacter baumannii infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The disease is generally self-limited when the causative factor is eliminated; and cure can be ensured with a short-term systemic steroids and a symptomatic treatment 5 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

et al. 2014

View full text Add to dashboard Cite

show abstract

Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients

Vallejo-Yagüe

Torre

Mohamad

et al. 2022

JCM

View full text Add to dashboard Cite

Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction, commonly caused by drugs. Available evidence mostly relies on small studies or case reports. We collected published AGEP case reports and, subsequently, described the patient characteristics, suspect and concomitant drugs, time to onset, disease management, and clinical prognosis. This study included 297 AGEP patients (64.3% women) obtained from 250 published case reports or case series with individual patient data. AGEP affected patients of all ages, but the majority of patients (88.2%) were ≥25 years old. The most frequently reported suspect drugs were anti-infectives for systemic use (36.5%), particularly antibacterials for systemic use (31.0%), and especially beta-lactam antibacterials (18.3%) and macrolides (4.3%). Other frequent suspect drugs were antineoplastics (12.2%), and anti-inflammatory/anti-rheumatic products (5.2%) plus hydroxychloroquine (12.8%). Mean time to onset was 9.1 days (standard deviation SD 13.94). Some patients developed fever (64.3%) and systemic involvement (18.9%), and most patients (76.4%) received pharmacological treatment for AGEP. Seven patients died, although five of them were already critically ill prior to AGEP. In conclusion, antibiotics remain the most common suspected cause of AGEP. While case mortality rate may be up to 2.5%, disentangling the role of AGEP on the fatal outcome from the role of the preexisting health conditions remains challenging.

show abstract

Cefixime-associated acute generalized exanthematous pustulosis: Rare cases in India

Kumar¹,

Kalaiselvan²,

Kumar³

et al. 2018

Indian J Pharmacol

View full text Add to dashboard Cite

BACKGROUND:Cefixime is a widely used third-generation cephalosporin schedule H1 drug, which is prescribed for the treatment of otitis media, respiratory tract infections, and uncomplicated urinary tract infections and is effective against infections caused by Enterobacteriaceae and Haemophilus influenzae species in India. The National Coordination Centre (NCC)-Pharmacovigilance Programme of India (PvPI), Indian Pharmacopoeia Commission (IPC), has received rare individual case safety reports (ICSRs) for acute generalized exanthematous pustulosis (AGEP) associated with the use of cefixime.MATERIALS AND METHODS:IPC, NCC-PvPI also acts as a national collaborating center for pharmacovigilance activities under the aegis of Ministry of Health and Family Welfare, Government of India; moreover, it is a member country in global pharmacovigilance system, World Health Organization-Uppsala Monitoring Centre, Sweden. There are more than 250 government/corporate medical colleges and hospitals acting as regional adverse drug reaction monitoring centers, actively functioning under PvPI. Furthermore, various stakeholders including consumers and pharmaceutical industries also play a significant contribution. NCC-PvPI receives spontaneous ICSRs from various stakeholders.RESULTS:NCC-PvPI, IPC has received a total of four spontaneous ICSRs for cefixime-induced AGEP. After clinical evaluation of reported ICSRs, a strong causal relationship was established between AGEP and cefixime and was supported by published literature and histopathological examination of skin. Based on the statistics with positive information component (IC025 Value: 0.17) and proportionality relative risk (PRR:3.4), PvPI considered cefixime-associated AGEP may be a potential signal.CONCLUSION:Hence, initially, AEGP is considered by PvPI as drug safety alert in July 2016. Therefore, to enhance the safety of population in rational usage of medication, as a result, there is a need for physicians and health-care professionals to sensitize about serious adverse reaction while prescribing the cefixime as signal in India.

show abstract

A Case of Acute Generalized Exanthematous Pustulosis Possibly Induced by Ritodrine

Cited by 3 publications

References 7 publications

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients

Cefixime-associated acute generalized exanthematous pustulosis: Rare cases in India

Contact Info

Product

Resources

About