A Case of Acquired Deficiency of Pituitary GH, PRL and TSH, Associated with Type 1 Diabetes Mellitus

Saito, Takatoshi; Tojo, Katsuyoshi; Kuriyama, Genshin; Murakawa, Yûichi; Fujimoto, Kei; Taniguchi, Kanta; Tanii, Kazuo; Katakami, Hideki; Hashimoto, Kozo; Tajima, Naoko

doi:10.1507/endocrj.51.287

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…In the present case, HLA typing detected DR9, which has been reported to be associated with increased susceptibility to both type 1 diabetes and Hashimoto's thyroiditis in Japanese autoimmune polyglandular syndrome patients (11). Moreover, we also identified HLA A24 and Cw3, which are frequently detected in individuals with lymphocytic hypophysitis (12,13). The clinical features, endocrine abnormalities and HLA status in the current patient may also be in accordance with the diagnosis of lymphocytic hypophysitis.…”

Section: Discussionsupporting

confidence: 82%

Hypopituitarism Possibly due to Lymphocytic Hypophysitis in a Patient with Type 1 Diabetes

et al. 2014

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Hypopituitarism often develops insidiously, and undiagnosed hypopituitarism can influence the glycemic profile of patients with type 1 diabetes. We herein report the case of a 49-year-old man with type 1 diabetes and Hashimoto's thyroiditis who experienced an unexplained improvement in his glycemic level and recurrent severe hypoglycemia, despite a reduction in the dose of insulin. Based on the patient's endocrinological findings, he was diagnosed with hypopituitarism possibly due to lymphocytic hypophysitis, as supported by positive results for human leukocyte antigen A24 and Cw3. Following the administration of hydrocortisone replacement therapy, his insulin requirement increased to a premorbid level, and the severe hypoglycemia resolved.

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Section: Discussionsupporting

confidence: 82%

Hypopituitarism Possibly due to Lymphocytic Hypophysitis in a Patient with Type 1 Diabetes

et al. 2014

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“…The role of pituitary hormone is unclear. A case of acquired deficiency of pituitary GH, PRL, and TSH associated with T1D mellitus was reported [ 81 ]. But basal TSH concentrations were unchanged with or without metabolic control in patients [ 82 ].…”

Section: Candidate Genes For Every Known Qtl Of Type 1 Diabetesmentioning

confidence: 99%

Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms

Gao¹,

Jiao²,

Xiong³

et al. 2008

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A systematic study has been conducted of all available reports in PubMed and OMIM (Online Mendelian Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic loci (QTL) of diabetes with the main focus on genes and polymorphisms. The major question is, What can the QTL tell us? Specifically, we want to know whether those genome regions differ from other regions in terms of genes relevant to diabetes. Which genes are within those QTL regions, and, among them, which genes have already been linked to diabetes? whether more polymorphisms have been associated with diabetes in the QTL regions than in the non-QTL regions.Our search revealed a total of 9038 genes from 26 type 1 diabetes QTL, which cover 667,096,006 bp of the mouse genomic sequence. On one hand, a large number of candidate genes are in each of these QTL; on the other hand, we found that some obvious candidate genes of QTL have not yet been investigated. Thus, the comprehensive search of candidate genes for known QTL may provide unexpected benefit for identifying QTL genes for diabetes.

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“…A 75-year-old man was admitted to the Jikei University Hospital for glycemic control of diabetes mellitus (DM) (12). Because he was anti-GAD antibody-positive, he was diagnosed with slowly progressive IDDM (SPIDDM) and thereafter treated with insulin.…”

Section: Introductionmentioning

confidence: 99%

Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans

Yamamoto¹,

Iguchi²,

Takeno³

et al. 2011

J. Clin. Invest.

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The pituitary-specific transcriptional factor-1 (PIT-1, also known as POU1F1), is an essential factor for multiple hormone-secreting cell types. A genetic defect in the PIT-1 gene results in congenital growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiency. Here, we investigated 3 cases of adult-onset combined GH, PRL, and TSH deficiencies and found that the endocrinological phenotype in each was linked to autoimmunity directed against the PIT-1 protein. We detected anti-PIT-1 antibody along with various autoantibodies in the patients' sera. An ELISA-based screening revealed that this antibody was highly specific to the disease and absent in control subjects. Immunohistochemical analysis revealed that PIT-1-, GH-, PRL-, and TSH-positive cells were absent in the pituitary of patient 2, who also had a range of autoimmune endocrinopathies. These clinical manifestations were compatible with the definition of autoimmune polyendocrine syndrome (APS). However, the main manifestations of APS-I -hypoparathyroidism and Candida infection -were not observed and the pituitary abnormalities were obviously different from the hypophysitis associated with APS. These data suggest that these patients define a unique "anti-PIT-1 antibody syndrome," related to APS.

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A Case of Acquired Deficiency of Pituitary GH, PRL and TSH, Associated with Type 1 Diabetes Mellitus

Cited by 9 publications

References 25 publications

Hypopituitarism Possibly due to Lymphocytic Hypophysitis in a Patient with Type 1 Diabetes

Hypopituitarism Possibly due to Lymphocytic Hypophysitis in a Patient with Type 1 Diabetes

Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms

Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans

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