A case of a male presenting with fever, myalgia, leucopenia, thrombocytopenia and acute kidney injury

Deng, Baocheng; Cui, Wei; Wen, Ying; Zhou, Ying; Wang, Wen; Liu, Pei

doi:10.1016/j.jcv.2012.06.025

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Serum myoglobin was tested in 5 patients, and only 1 had an elevated serum myoglobin. One patient with a Ccr of 19.6 ml/min had a CK value exceeding the maximum (>23,000 U/L) and myoglobin value (>1000 U/L), and the renal injury was considered to be associated with rhabdomyolysis [ 18 ]. A marked increase (>1540 U/l) in the creatinine kinase level occurred in 15 (13.0%) of 115 patients.…”

Section: Resultsmentioning

confidence: 99%

“…In this study, AST levels were disproportionately higher than ALT levels in SFTS patients, which were dramatically higher (2–6.2 times higher) in fatal than in non-fatal cases. Some of patients with elevated markers of liver damage had complications, such as pancreatitis, renal insufficiency, rhabdomyolysis [ 18 ], sepsis and shock. This suggests that elevated AST/ALT ratio is not only associated with liver damage, but also with damage to other tissues, such as muscle, kidney, and pancreas, which could be a direct result of virus infection (and injury) and/or an indirect consequence of cell necrosis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Features and Factors Associated with Severity and Fatality among Patients with Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection in Northeast China

Deng

Zhou

Zhang³

et al. 2013

PLoS ONE

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BackgroundIn 2009, severe fever with thrombocytopenia syndrome virus (SFTSV) was identified as a novel member of the genus phlebovirus in the Bunyaviridae family in China. The detailed clinical features of cases with SFTSV infection have not been well described, and the risk factors for severity among patients and fatality among severe patients remain to be determined.Methodology/Principal FindingsClinical and laboratory features of 115 hospitalized patients with SFTSV infection during the period from June 2010 to December 2011 in Northeast China were retrospectively reviewed. We assessed the risk factors associated with severity in confirmed cases and fatality in severe cases by multivariate analysis. One hundred and three (89.6%) of 115 patients presented with multiple organ dysfunction, and 22 (19.1%) of 115 proceeded to the stage of life threatening multiple organ failure. Of the 115 patients, 14 fatalities (12.2%) were reported. Multivariate analysis demonstrated that the independent predictors of risk for severity were: albumin ≤30 g/l (OR, 8.09; 95% CI, 2.58-25.32), APTT ≥ 66 seconds (OR, 14.28; 95% CI, 3.28-62.24), sodium ≤130 mmol/l (OR, 5.44; 95% CI, 1.38-21.40), and presence of neurological manifestations (OR, 7.70; 95% CI, 1.91-31.12). Among patients with severe disease, presence of acute lung injury/acute respiratory distress syndrome (HR, 4.59; 95% CI, 1.48–14.19) and disseminated intravascular coagulation (HR, 4.24; 95% CI, 1.38–13.03) were independently associated with fatality.Conclusions/SignificanceSFTSV infection may present with more severe symptoms and laboratory abnormalities than hitherto reported. Due to infection with a novel bunyavirus, the patients may sufferer multiple organ dysfunction and die of multiple organ failure. In the clinical assessment of any case of SFTS, independent factors relating to prognosis need to be taken into account by clinicians.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Features and Factors Associated with Severity and Fatality among Patients with Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection in Northeast China

Deng

Zhou

Zhang³

et al. 2013

PLoS ONE

Self Cite

136

160

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show abstract

“…SFTS cases complicated mainly by rhabdomyolysis in initial presentation is rarely reported. To our knowledge, only one case has been reported [13]. However, considering that myalgia was observed in 74% of patients with SFTS and elevated creatinine kinase was found in up to 79%, the actual incidence of rhabdomyolysis associated with SFTS may be higher [614].…”

Section: Discussionmentioning

confidence: 99%

Severe Fever with Thrombocytopenia Syndrome Presenting with Rhabdomyolysis

et al. 2017

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging febrile illness. While many kinds of severe complications including acute renal failure have been reported, rhabdomyolysis is rarely reported in association with SFTS. A 54-year-old female farmer was admitted with fever and diffuse myalgia. Laboratory finding showed thrombocytopenia, leukopenia, azotemia, extremely elevated muscle enzyme levels and myoglobinuria. We describe a fatal case of rhabdomyolysis with acute renal failure complicated by SFTS.

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Clinical Aspects of SFTS

Yasukawa

Azuma

2019

Severe Fever With Thrombocytopenia Syndrome

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A case of a male presenting with fever, myalgia, leucopenia, thrombocytopenia and acute kidney injury

Cited by 3 publications

References 18 publications

Clinical Features and Factors Associated with Severity and Fatality among Patients with Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection in Northeast China

Clinical Features and Factors Associated with Severity and Fatality among Patients with Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection in Northeast China

Severe Fever with Thrombocytopenia Syndrome Presenting with Rhabdomyolysis

Clinical Aspects of SFTS

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