A Case of a Human-Papillomavirus-60-Induced Wart with Clinical Appearance of Both Pigmented and Ridged Warts

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A new type of skin wart was observed in a Japanese patient. It was characterized by intracytoplasmic inclusions with a ‘fibrillar’ structure which were distinct from previously described wart-associated inclusions. The papillomavirus (HPV)-group-specific antigen could be detected, but DNA hybridization and PCR amplification using probes or PCR primers specific for the main skin HPV genotypes (including HPV-63 which is also associated with ‘filamentous’ inclusions) were negative. We consider that this cytopathic effect could correspond to an HPV genotype which has not yet been characterized.

Section: Discussionmentioning

confidence: 99%

“…1). The macroscopic features were quite different from those of HPV-1-induced myrmecia warts [2, 3, 4, 5]or punctate keratotic warts associated with HPV-63 [4, 5]but somewhat resembled those of HPV-2/-27/-57-induced common warts [7, 8]or HPV-4/-60/-65-induced pigmented warts [4, 6, 16]. However, no pig…”

Section: Case Reportmentioning

confidence: 97%

A Case of Viral Warts with Particular Fibrillar Intracytoplasmic Inclusion Bodies

Egawa

Honda²,

Ono³

et al. 2000

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“…Using primers specific for these viruses, we identified a putative novel type of γ-papillomavirus that is most closely related to, though very distinct from (69% homologous in the amplified L1 region), HPV60. The warts caused by HPV60 show diverse clinical presentations including pigmented warts [40,41,58,59], palmoplantar epidermoid cysts [60,61,62,63,64] and ridged warts [59,61,65], but lesions clinically and histologically resembling EV have not been reported previously.…”

Section: Discussionmentioning

confidence: 99%

Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

Kawai

Egawa²,

Kiyono³

et al. 2009

Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by widespread and persistent cutaneous lesions caused by β-papillomaviruses. Rare cases of acquired EV-like eruption associated with β-papillomavirus infection have been reported in immunosuppressed patients. We report a case of acquired EV-like eruption in an immunosuppressed patient with adult T-cell leukemia. The cutaneous lesions clinically resembled pityriasis versicolor and exhibited the typical histological features of EV, but in some areas of the same biopsy specimen characteristic homogeneous intracytoplasmic inclusion bodies were observed. Although β-papillomavirus was not detected by highly sensitive polymerase chain reaction, a putative novel type of γ-papillomavirus was identified. This is the first documentation of an association between EV-like eruption and γ-papillomavirus infection.

“…It is quite possible that the eccrine ducts are targeted specifically by certain HPV types [8, 9]and that the other areas are targeted by other types in the deep rete ridges of the palmoplantar skin.…”

Section: Discussionmentioning

confidence: 99%

Do Human Papillomaviruses Target Epidermal Stem Cells?

Egawa

2003

Little is known about the target cells of human papillomaviruses (HPVs). The clinical and histological analyses of very early lesions of palmoplantar warts indicate that not only the warts initially developed exclusively in the ridges of the skin, but also that the initial histological changes were restricted to the deep ridges of the epidermis, where epidermal stem cells are thought to exist in the palmoplantar skin. This suggests that HPV infection targets the stem cells.